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Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19.

SpO2/FiO2的连续可用比率作为COVID-19的重症监护患者的无创预后标志物。

  • 影响因子:3.68
  • DOI:10.1186/s12931-020-01455-4
  • 作者列表:"Lu X","Jiang L","Chen T","Wang Y","Zhang B","Hong Y","Wang J","Yan F
  • 发表时间:2020-07-22
Abstract

RATIONALE:Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. METHODS:Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. RESULTS:A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13). CONCLUSIONS:The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.

摘要

基本原理: 氧饱和度与吸入氧比例 (SpO2/FiO2) 被描述为COVID-19不良结局的潜在预测因子,但不考虑其时变行为。 方法: SpO2/FiO2的预后价值通过联合建模SpO2/FiO2的纵向反应和从280例重症和危重症 (重症监护) 患者中检索到的事件发生时间数据来评估COVID-19。 结果: 观察到非幸存者的SpO2/FiO2从第一次到第二次测量急剧下降,并且证明了平方根SpO2/FiO2和死亡风险之间的强烈关联,标记物的单位下降对应于死亡风险增加1.82倍 (95% CI: 1.56-2.13)。 结论: 目前的研究表明,SpO2/FiO2可以作为一种非侵入性预后标志物,以促进治疗的早期调整,从而提高总生存率。

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发表时间:2020-03-01
DOI:10.1016/j.ajem.2019.05.036
作者列表:["Strawn M","Xu KT","Brodeur M","Youngblood G","Richman P"]

METHODS:BACKGROUND:There is a commonly held belief that overweight women are more likely to offer contaminated urine samples (UAs) in the emergency department (ED) than women with normal body mass index (BMI). However, there is a paucity of research evaluating this potential concern. OBJECTIVE:We hypothesized that patients with higher BMI would be more likely to provide contaminated urine samples than women with low BMI. METHODS:This was a prospective, observational, cohort study evaluating consenting, adult, women that provided a clean catch, mid-stream sample at an inner-city ED. UAs were ordered at the discretion of the caring physician, cultures based on standardized parameters. The primary outcome parameter was the presence of UA contamination as defined by our microbiology lab. Demographic/historical data and BMI were recorded on a structured data sheet. Categorical data were analyzed by chi-square; continuous data by t-tests. Multivariable logistic regression was performed to control for confounding. RESULTS:There were 350 patients in the study group; 22% overweight, 35% obese, 17% morbidly obese, mean BMI 31. 5, and 60% provided contaminated specimens. The mean BMIs of the subjects with contaminated vs. uncontaminated UAs were significantly different (32.7 ± 10.2 vs 29.7 ± 8.8, p < 0.01). Within our multiple variable logistic regression model, obese and morbidly obese patients were more likely to provide contaminated UAs, while there were no significant associations for contamination with other variables except for hypertension (OR = 1.85, p = 0.02). CONCLUSION:Obesity was significantly associated with contamination of clean catch mid-stream samples in our population.

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影响因子:0.85
发表时间:2020-01-02
来源期刊:Laboratory medicine
DOI:10.1093/labmed/lmz025
作者列表:["Tang J","Jiang Y","Ge Z","Wu H","Chen H","Dai J","Gu Y","Mao X","Lu J"]

METHODS:OBJECTIVE:To determine whether the performance of a new quantum dots-based point-of-care test (POCT) devices is qualified for procalcitonin testing. METHODS:Finger-prick and venous blood specimens from 153 patients were measured with a quantum dots-based POCT device; the results were compared with those from the reference method. RESULTS:The quantum dots-based POCT device correlated well with the reference method in measuring plasma, venous whole blood, and finger-prick blood. No significant bias was observed (-0.08 ng/mL). At 0.5 ng per mL cutoff value, the concordances were 96.6%, 94.6%, and 90.5% for plasma, venous whole blood, and finger-prick blood, respectively. And at 2 ng per mL cutoff value, the concordances were 98.0%, 96.6%, and 95.3%, respectively. CONCLUSIONS:The quantum dots-based POCT device measured procalcitonin with multiple specimen types, high sensitivity, wide detection range, and short turnaround time. It would allow a more widespread use of procalcitonin and help lessen the burden of overcrowding in healthcare facilities in China.

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影响因子:3.23
发表时间:2020-02-01
DOI:10.5858/arpa.2019-0045-CP
作者列表:["Barkan GA","Tabatabai ZL","Kurtycz DFI","Padmanabhan V","Souers RJ","Nayar R","Sturgis CD"]

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临床化学检测方向

临床化学检测,用于诊断或治疗疾病的实验室检测,常用的检查物有:血液、尿液、组织和体液等。

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