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Factors associated with mortality in children under five years old hospitalized for Severe Acute Malnutrition in Limpopo province, South Africa, 2014-2018: A cross-sectional analytic study.

南非林波波省因严重急性营养不良住院的5岁以下儿童死亡率相关因素,2014-2018: 一项横断面分析研究。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0232838
  • 作者列表:"Gavhi F","Kuonza L","Musekiwa A","Motaze NV
  • 发表时间:2020-05-08
Abstract

BACKGROUND:In South Africa, 30.9% of children under five years with Severe Acute Malnutrition (SAM) died in 2018. We aimed to identify factors associated with mortality among children under five years hospitalized with SAM in Limpopo province, South Africa. METHODS:We conducted a cross-sectional study including children under five years admitted with SAM from 2014 to 2018 in public hospitals of Limpopo province. We extracted socio-demographic and clinical data from hospital records. We used logistic regression to identify factors associated with mortality. FINDINGS:We included 956 children, 50.2% (480/956) male and 49.8% (476/956) female. The median age was 13 months (inter quartile range: 9-19 months). The overall SAM mortality over the study period was 25.9% (248/956). The most common complications were diarrhea, 63.8% (610/956), and lower respiratory tract infections (LRTIs), 42.4% (405/956). Factors associated with mortality included herbal medication use (adjusted Odds Ratio (aOR): 2.2, 95% Confidence Interval (CI): 1.4-3.5, p = 0.001), poor appetite (aOR: 2.7, 95% CI: 1.4-5.2, p = 0.003), Mid-upper circumference (MUAC) <11.5 cm (aOR: 3.0, 95% CI: 1.9-4.7, p<0.001), lower respiratory tract infections (LRTIs) (aOR: 1.6, 95% CI: 1.2-2.0, p<0.001), anemia (aOR: 2.5, 95% CI: 1.1-5.3, p = 0.021), hypoglycemia (aOR: 12.4, 95% CI: 7.1-21.8, p<0.001) and human immunodeficiency virus (HIV) infection (aOR: 2.3, 95% CI: 1.6-3.3, p<0.001). INTERPRETATION:Herbal medication use, poor appetite, LRTIs, anemia, hypoglycemia, and HIV infection were associated with mortality among children with SAM. These factors should guide management of children with SAM.

摘要

背景: 在南非,30.9% 患有严重急性营养不良 (SAM) 的5岁以下儿童在2018年死亡。我们旨在确定与南非林波波省5岁以下儿童SAM住院死亡率相关的因素。 方法: 我们进行了一项横断面研究,包括2014年至2018年在林波波省公立医院接受SAM治疗的5岁以下儿童。我们从医院记录中提取社会人口统计学和临床数据。我们使用逻辑回归来确定与死亡率相关的因素。 结果: 我们纳入了956名儿童,50.2% 名 (480/956) 男性和49.8% 名 (476/956) 女性。中位年龄为13个月 (四分位距: 9-19个月)。研究期间的总SAM死亡率为25.9% (248/956)。最常见的并发症为腹泻 (63.8% (610/956)) 和下呼吸道感染 (LRTIs) (42.4% (405/956))。与死亡率相关的因素包括草药用药 (校正比值比 (aOR): 2.2,95% 置信区间 (CI): 1.4-3.5,p = 0.001),食欲差 (aOR: 2.7,95% CI: 1.4-5.2,p = 0.003),上中围 (MUAC) <11.5厘米 (aOR: 3.0,95% CI:1.9-4.7,p<0.001),下呼吸道感染 (LRTIs) (aOR: 1.6,95% CI: 1.2-2.0,p<0.001),贫血 (aOR: 2.5,95% CI: 1.1-5.3,p = 0.021),低血糖 (aOR: 12.4,95% CI: 7.1-21.8,p<0.001) 和人类免疫缺陷病毒毒 (HIV) 感染(aOR: 2.3,95% CI: 1.6-3.3,p<0.001)。 解读: 使用草药、食欲不佳、LRTIs、贫血、低血糖和HIV感染与SAM患儿的死亡率相关。这些因素应该指导SAM患儿的管理。

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影响因子:2.36
发表时间:2020-01-01
来源期刊:Platelets
DOI:10.1080/09537104.2019.1581922
作者列表:["Szanto T","Nummi V","Jouppila A","Brinkman HJM","Lassila R"]

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