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Outcomes of Renal Transplant Recipients after Percutaneous Coronary Intervention.

经皮冠状动脉介入治疗后肾移植受者的预后。

  • 影响因子:2.86
  • DOI:10.1016/j.amjcard.2020.02.007
  • 作者列表:"Nakao M","Yamaguchi J","Satomi N","Ebihara S","Tanaka K","Otsuki H","Inagaki Y","Jujo K","Arashi H","Hagiwara N
  • 发表时间:2020-05-01
Abstract

:Renal transplantation (RT) can improve life expectancy in hemodialysis (HD) patients. However, little is known about the outcomes of renal transplant recipients after percutaneous coronary intervention (PCI). This study aimed to elucidate the effect of RT on clinical outcomes after PCI. Renal transplant recipients who underwent PCI from 2002 to 2017 were enrolled. To evaluate the effectiveness of RT, we retrospectively reviewed HD patients who underwent PCI. Propensity-score matching was performed using logistic regression to control for differences in baseline characteristics. The primary outcome was the incidence of major adverse cardiac events. After propensity matching, patients were classified into the RT (n = 50) group and HD (n = 50) group. Kaplan-Meier analysis revealed that the incidence of major adverse cardiac events was significantly lower in the RT group than in the HD group (p < 0.0001). Moreover, RT was associated with a lower risk for all-cause death (odds ratio 0.04; 95% confidence interval 0.002 to 0.03; p = 0.0054) and target vessel revascularization (OR 0.27; 95% CI 0.07 to 0.79; p = 0.015). RT may improve clinical outcomes after PCI, and it is encouraged for HD patients to increase life expectancy and reduce the occurrence of adverse events after PCI. Further research would be warranted to support this finding.

摘要

: 肾移植 (RT) 可改善血液透析 (HD) 患者的预期寿命。然而,对经皮冠状动脉介入治疗 (PCI) 后肾移植受者的预后知之甚少。本研究旨在阐明RT对PCI术后临床结局的影响。纳入2002年至2017年接受PCI的肾移植受者。为了评估RT的有效性,我们回顾性分析了接受PCI的HD患者。使用逻辑回归进行倾向评分匹配以控制基线特征的差异。主要结局是主要不良心脏事件的发生率。倾向匹配后,将患者分为RT (n = 50) 组和HD (n = 50) 组。Kaplan-Meier分析显示,RT组主要不良心脏事件发生率显著低于HD组 (p <0.0001)。此外,RT与较低的全因死亡风险 (比值比0.04; 95% 置信区间0.002至0.03; P = 0.0054) 和靶血管血运重建 (OR 0.27; 95% CI 0.07至0.79; P = 0.015) 相关。RT可能改善PCI术后的临床结局,鼓励HD患者延长预期寿命,减少PCI术后不良事件的发生。需要进一步的研究来支持这一发现。

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DOI:10.1111/nep.13588
作者列表:["Yeh EL","Chen CH","Huang SC","Huang YC"]

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肾透析方向

肾脏的一种替代治疗方式,主要是用于肾脏功能的减退。

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