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Abnormal glucose tolerance and the 50-gram glucose challenge test in Cystic fibrosis.

囊性纤维化的糖耐量异常和 50 克葡萄糖激发试验。

  • 影响因子:2.88
  • DOI:10.1016/j.jcf.2020.01.003
  • 作者列表:"Sheikh S","Localio AR","Kelly A","Rubenstein RC
  • 发表时间:2020-01-20
Abstract

:Diabetes has emerged as a major co-morbidity in cystic fibrosis (CF). The 75 g oral glucose tolerance test (OGTT) is used to screen for CF-related diabetes (CFRD) but is inconvenient, and adherence to screening is poor. The 50 g glucose challenge test (GCT) is shorter, performed non-fasting, and may serve to pre-screen the subset of individuals requiring confirmatory OGTT. We performed a pilot study in twenty-seven CF individuals across the glucose tolerance spectrum to test whether the GCT could identify subjects with abnormal glucose tolerance defined as 2-h OGTT glucose ≥7.8 mmol/L (2 h-AGT) or 1-h defined as 1-hr OGTT glucose ≥11.1 mmol/L (1 h-AGT). A GCT threshold of 8.1 mmol/L was 73% sensitive and 63% specific for 2hr-AGT and 80% sensitive and 65% specific for 1hr-AGT. Therefore, a screening GCT may reduce need for confirmatory OGTT for identifying AGT but a larger study is warranted to identify a robust cutoff for CFRD.

摘要

: 糖尿病已成为囊性纤维化 (CF) 的主要共病。75g 口服葡萄糖耐量试验 (OGTT) 用于筛查 CF 相关糖尿病 (CFRD) 但不方便,筛查依从性差。50g 葡萄糖激发试验 (GCT) 较短,非禁食,可用于预先筛选需要确证 OGTT 的个体子集。我们在 27 名跨葡萄糖耐量谱的 CF 个体中进行了一项初步研究,以测试 GCT 是否能够识别定义为 2 h OGTT 葡萄糖 ≥ 7.8 mmol/L 的异常糖耐量受试者 (2 h-AGT) 或定义为 1-hr OGTT 葡萄糖 ≥ 11.1 mmol/L 的 1-h (1 h-AGT)。8.1 mmol/L 的 GCT 阈值对 2hr-AGT 的敏感性和特异性分别为 73% 和 63%,对 1hr-AGT 的敏感性和特异性分别为 80% 和 65%。因此,筛查 GCT 可能会减少确定 AGT 的验证性 OGTT 需求,但需要更大规模的研究来确定 CFRD 的稳健截止日期。

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