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Quality-of-life assessment in French patients with metastatic melanoma in real life.

现实生活中法国转移性黑色素瘤患者的生活质量评估。

  • 影响因子:4.78
  • DOI:10.1002/cncr.32554
  • 作者列表:"Kandel M","Dalle S","Bardet A","Allayous C","Mortier L","Dutriaux C","Guillot B","Leccia MT","Dalac S","Legoupil D","Saiag P","Montaudie H","Arnault JP","Brunet-Possenti F","Grob JJ","DeQuatrebarbes J","Beylot-Barry M","Lesimple T","Aubin F","Maubec E","Granel-Brocard F","Stoebner PE","Dupuy A","Dreno B","Michiels S","Lebbe C","Borget I
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Significant progress was recently observed in the treatment of metastatic melanoma (MM). With >50% of patients now reaching a second line of treatment and a significant improvement in the survival rate, an assessment of quality of life (QoL) during the whole course of the disease becomes necessary. The objective of this study was to describe the QoL of patients with MM in France, from their diagnosis of advanced disease to their death, in real life. METHODS:QoL data were collected through MelBase, a prospective, French, multicentric cohort dedicated to the follow-up of adults with MM. QoL was assessed using the EuroQoL-5D questionnaire and the Functional Assessment of Cancer Treatment (FACT)-Melanoma questionnaire at the time of study inclusion, every 3 months, and at the time of each treatment change until death. To assess longitudinal changes from baseline to death, mixed-effect models for repeated-measures analyses were used to control for baseline covariates. RESULTS:QoL was assessed in 1435 patients who were included in the study between 2013 and 2018. The median follow-up was 9.4 months, and 47% of patients died during follow-up. During first-line treatment, the model-based, mean utility score was 0.830 (95% CI, 0.818-0.843), the mean FACT-General score was 77.22 (95% CI, 76.23-78.22), and the mean FACT-Melanoma score was 129.46 (95% CI, 128.02-130.90). At the time of a change in treatment line, there was a decrease of -0.027 (95% CI, -0.03, -0.02) in the utility score, -1.82 (95% CI, -1.88, -1.76) in the FACT-General score, and -2.98 (95% CI, -3.05, -2.91) in the FACT-Melanoma score compared with first-line treatment. CONCLUSIONS:In the MelBase cohort, the QoL among patients with MM seems to be fairly stable over the whole disease course, although a small but significant decrease at time therapy is changed is observed.

摘要

背景: 最近在治疗转移性黑色素瘤 (MM) 方面观察到重大进展。随着> 50% 的患者现在达到第二线治疗,生存率显著提高,在整个疾病过程中评估生活质量 (QoL) 成为必要。本研究的目的是描述法国MM患者从诊断为晚期疾病到死亡的生活质量。 方法: 通过MelBase收集QoL数据,MelBase是一个致力于成人MM随访的前瞻性、法国、多中心队列。在研究纳入时使用EuroQoL-5D问卷和癌症治疗功能评估 (FACT)-黑色素瘤问卷评估QoL,每 3 个月,并在每次治疗的时间改变,直到死亡。为了评估从基线到死亡的纵向变化,使用重复测量分析的混合效应模型来控制基线协变量。 结果: 在 2013 年至 1435 年期间,对纳入研究的 2018 例患者进行了QoL评估。中位随访时间为 9.4 个月,47% 的患者在随访期间死亡。一线治疗期间,基于模型的平均效用评分为 0.830 (95% CI,0.818-0.843),平均事实-一般评分为 77.22 (95% CI,76.23-78.22),平均事实-黑色素瘤评分为 129.46 (95% CI,128.02-130.90)。在治疗线改变时,效用评分降低了-0.027 (95% CI,-0.03,-0.02),-1.82 (95% CI,-1.88,-1.76) 在事实-一般评分中,-2.98 (95% CI,-3.05,-2.91)在事实-黑色素瘤评分与一线治疗比较。 结论: 在MelBase队列中,MM患者的QoL在整个病程中似乎相当稳定,尽管在治疗改变时观察到小幅但显著的下降。

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影响因子:6.50
发表时间:2020-03-31
来源期刊:Cancer letters
DOI:10.1016/j.canlet.2019.12.039
作者列表:["Zhou Z","Zhou Q","Wu X","Xu S","Hu X","Tao X","Li B","Peng J","Li D","Shen L","Cao Y","Yang L"]

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