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Comparison of MRI, PSMA PET/CT, and Fusion PSMA PET/MRI for Detection of Clinically Significant Prostate Cancer.

MRI、PSMA PET/CT和融合PSMA PET/MRI检测临床显著前列腺癌的比较。

  • 影响因子:1.48
  • DOI:10.1097/RCT.0000000000001116
  • 作者列表:"Arslan A","Karaarslan E","Güner AL","Sağlıcan Y","Tuna MB","Özışık O","Kural AR
  • 发表时间:2021-03-01
Abstract

PURPOSE:The aim of our study is to compare the efficacy of positron emission tomography (PET) and magnetic resonance imaging (MRI) for detecting intraprostatic lesions in patients with clinically significant prostate cancer who underwent radical prostatectomy; additionally, investigate the benefits of rostate-specific membrane antigen (PSMA) PET-MR software fusion images to the diagnosis. METHODS:Thirty patients, who underwent radical prostatectomy between June 2015 and April 2018, were included in the study. Subjects with gallium PSMA PET-CT and multiparametric prostate MRI performed according to Prostate Imaging Reporting and Data System v2 criteria in our clinic were included in the study. 68Ga-PSMA PET-CT images were fused with MR sequences for analysis. RESULTS:The mean age of cases was 63.2 years (ranged from 45 to 79 years). Index lesions of 29 cases were detected by MRI and 22 of them by PET CT. Both modalities were found to be less sensitive for detection of bilaterality and multifocality (42.85% and 20% for MRI, 28.57% and 20% for PET CT, respectively). There was no statistically significant difference between modalities. It was observed that if a clinically significant tumor focus was not detected by MRI, it was small (6 mm or less) in diameter or had a low Gleason score. CONCLUSIONS:Software fusion PSMA PET-MRI increased the sensitivity of the index lesion identification compared with PSMA PET-CT and also increased the sensitivity of real lesion size identification compared with multiparametric prostate MRI.

摘要

目的: 本研究的目的是比较正电子发射断层扫描 (PET) 和磁共振成像 (MRI) 对接受根治性前列腺切除术的临床显著前列腺癌患者前列腺内病变的检测效果; 此外,研究rostate特异性膜抗原 (PSMA) 的益处pet-mr软件融合图像进行诊断。 方法: 本研究纳入了2015年6月至2018年4月期间接受根治性前列腺切除术的30例患者。本研究包括根据我们诊所的前列腺成像报告和数据系统v2标准进行镓PSMA pet-ct和多参数前列腺MRI的受试者。68Ga-PSMA pet-ct图像与MR序列融合用于分析。 结果: 病例平均年龄63.2岁 (45 ~ 79岁)。MRI检出指标性病变29例,PET/CT检出22例。发现两种方式对检测双侧性和多焦性的敏感性较低 (MRI分别为42.85% 和20%,PET CT分别为28.57% 和20%)。两种模式之间没有统计学显著差异。观察到,如果MRI未检测到临床上显著的肿瘤病灶,则其直径较小 (6毫米或更小) 或具有低Gleason评分。 结论: 与PSMA pet-ct相比,软件融合PSMA pet-mri增加了指示病灶识别的灵敏度,并且与多参数前列腺MRI相比,增加了真实病灶大小识别的灵敏度。

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影响因子:2.68
发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

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影响因子:2.06
发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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