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Normocalcaemic hyperparathyroidism and primary hyperparathyroidism: least significant change for adjusted serum calcium.

正常钙血症甲状旁腺功能亢进和原发性甲状旁腺功能亢进: 调整后血清钙的变化最小。

  • 影响因子:5.04
  • DOI:10.1530/EJE-20-0634
  • 作者列表:"Schini M","Jacques R","Oakes E","Peel N","Walsh JS","Eastell R
  • 发表时间:2021-01-01
Abstract

Introduction:The least significant change (LSC) is a term used in individuals in order to evaluate whether one measurement has changed significantly from the previous one. It is widely used when assessing bone mineral density (BMD) scans. To the best of our knowledge, there no such estimate available in the literature for patients with disorders of calcium metabolism. Our aim was to provide an estimate of the least significant change for albumin-adjusted calcium in patients with normocalcaemic hyperparathyroidism (NPHPT) and primary hyperparathyroidism (PHPT). Methods:We used the within-subject standard deviatio calculated in a population of NPHPT and PHPT patients and multiplied it by 2.77. Results:The LSC for NPHPT and PHPT were found to be 0.25 and 0.24 mmol/L, respectively (1.00 and 0.96 mg/dL). In clinical practice, the value of 0.25 mmol/L could be used. Discussion:The least significant change given, could be used in two ways in these patients. First, it gives a range to which values are expected. This can provide some reassurance for the patient and the physician in cases of intermittent hypercalcaemia. Moreover, it can be a marker of whether an individual has an actual significant change of his calcium after parathyroid surgery.

摘要

简介: 最低显著性变化 (LSC) 是一个用于个体的术语,用于评估一个测量是否与前一个测量有显著变化。它在评估骨矿物质密度 (BMD) 扫描时被广泛使用。据我们所知,对于钙代谢紊乱的患者,文献中没有这样的估计。我们的目的是估计正常钙血症甲状旁腺功能亢进 (NPHPT) 和原发性甲状旁腺功能亢进 (PHPT) 患者中白蛋白调整钙的最低显著性变化。 方法: 我们使用在NPHPT和PHPT患者人群中计算的受试者内标准偏差,并将其乘以2.77。 结果: NPHPT和PHPT的LSC分别为0.25和0.24 mmol/L (1.00和0.96 mg/dL)。在临床实践中,可以使用0.25 mmol/L的值。 讨论: 给出的最不显著的变化,可以在这些患者中以两种方式使用。首先,它给出了一个预期值的范围。这可以在间歇性高钙血症的情况下为患者和医生提供一些保证。此外,它可以是个体在甲状旁腺手术后其钙是否具有实际显著变化的标志物。

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