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Serum insulin is associated with right ventricle function parameters and lung volumes in subjects free of cardiovascular disease.

血清胰岛素与无心血管疾病受试者的右心室功能参数和肺容量相关。

  • 影响因子:5.04
  • DOI:10.1530/EJE-20-1010
  • 作者列表:"Krüchten RV","Lorbeer R","Rospleszcz S","Storz C","Askani E","Kulka C","Rathmann W","Peters A","Karrasch S","Bamberg F","Schlett C","Mujaj B
  • 发表时间:2021-02-01
Abstract

Background:Diabetes mellitus is an established risk factor for cardiovascular diseases. Even impaired levels of glucose and insulin might harm organ function prior to diabetes onset. Whether serum glucose or insulin plays a direct role in cardiac dysfunction or lung volume reduction remains unclear. The aim was to investigate the relationship between glucose and insulin with the right ventricle and lung volumes within KORA-MRI FF4 study. Methods:From the KORA-MRI FF4 cohort study 337 subjects (mean age 55.7 ± 9.1 years; 43% women) underwent a whole-body 3T MRI scan. Cardiac parameters derived from a cine-steady-state free precession sequence using cvi42. MRI-based lung volumes derived semi-automatically using an in-house algorithm. Fasting serum glucose, fasting insulin levels, and HOMA index were calculated in all study subjects. Linear regression analyses were performed to assess the relationships between glucose and insulin levels with right ventricle volumes and lung volumes adjusted for age, sex, BMI, and cardiovascular risk factors. Results:In univariate and multivariate-adjusted models, high serum insulin was inversely associated with end-diastolic volume (β = -12.43, P < 0.001), end-systolic volume (β = -7.12, P < 0.001), stroke volume (β = -5.32, P < 0.001), but not with ejection fraction. The association remained significant after additional adjustment for lung volumes. Similarly, serum insulin was inversely associated with lung volume (β = -0.15, P = 0.04). Sensitivity analysis confirmed results after excluding subjects with known diabetes. Conclusions:Serum insulin was inversely associated with right ventricle function and lung volumes in subjects from the general population free of cardiovascular disease, suggesting that increased insulin levels may contribute to subclinical cardiopulmonary circulation impairment.

摘要

背景: 糖尿病是心血管疾病的危险因素。即使葡萄糖和胰岛素水平受损也可能在糖尿病发作前损害器官功能。血清葡萄糖或胰岛素是否在心功能障碍或肺体积减少中起直接作用仍不清楚。目的是在KORA-MRI FF4研究中研究葡萄糖和胰岛素与右心室和肺容量之间的关系。 方法: 来自KORA-MRI FF4队列研究的337名受试者 (平均年龄55.7 ± 9.1岁; 43% 名女性) 接受了全身3t MRI扫描。使用cvi42从电影稳态自由进动序列导出的心脏参数。使用内部算法半自动导出基于MRI的肺容积。计算所有研究对象的空腹血糖、空腹胰岛素水平和HOMA指数。进行线性回归分析,以评估葡萄糖和胰岛素水平与右心室容积和肺容积之间的关系,调整年龄,性别,BMI和心血管危险因素。 结果: 在单变量和多变量校正模型中,高血清胰岛素与舒张末期容积 (β = -12.43,P <0.001) 、收缩末期容积 (β = -7.12,P <0.001) 、每搏输出量 (β = -5.32,P <0.001) 、但与射血分数无关。在对肺容量进行额外调整后,该相关性仍然显著。类似地,血清胰岛素与肺体积呈负相关 (β = -0.15,P = 0.04)。在排除已知患有糖尿病的受试者后,敏感性分析证实了结果。 结论: 在无心血管疾病的普通人群中,血清胰岛素与右心室功能和肺容量呈负相关,提示胰岛素水平升高可能导致亚临床心肺循环障碍。

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