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Functional Activation Patterns of Deep Brain Stimulation of the Anterior Nucleus of the Thalamus.

丘脑前核深部脑刺激的功能激活模式。

  • 影响因子:1.52
  • DOI:10.1016/j.wneu.2020.01.108
  • 作者列表:"Middlebrooks EH","Lin C","Okromelidze L","Lu CQ","Tatum WO","Wharen RE Jr","Grewal SS
  • 发表时间:2020-01-27
Abstract

BACKGROUND:Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a recently approved therapy for patients with drug-resistant epilepsy. To date, there is a poor understanding of the mechanism of action and lack of in vivo biomarkers. We propose a method for investigating the in vivo stimulation effects using blood-oxygen-level dependent (BOLD) MRI and present the brain activation pattern associated with ANT DBS. METHODS:Two patients undergoing ANT DBS for epilepsy underwent BOLD MRI using a block design after the DBS was programmed to alternate ON/OFF in 30 second blocks. The scanner was triggered utilizing surface electrophysiological recording to detect the DBS cycle. Nine total runs were obtained and were analyzed using a general linear model. RESULTS:Active ANT stimulation produced activation within several areas of the brain, including the thalamus, bilateral anterior cingulate and posterior cingulate cortex, precuneus, medial prefrontal cortex, amygdala, ventral tegmental area, hippocampus, striatum, and right angular gyrus. CONCLUSIONS:Utilizing block-design BOLD MRI, we were able to show widespread activation resulting from ANT DBS. Overlap with multiple areas of both the default mode and limbic networks was shown suggesting that these nodes may modulate the effect of seizure control with ANT DBS.

摘要

背景: 丘脑前核 (ANT) 深部脑刺激 (DBS) 是最近批准用于耐药性癫痫患者的治疗方法。到目前为止,人们对作用机制的理解很差,缺乏体内生物标志物。我们提出了一种使用血氧水平依赖性 (BOLD) MRI 研究体内刺激效应的方法,并呈现与 ANT DBS 相关的脑激活模式。 方法: 2 例因癫痫接受 ANT DBS 的患者在 DBS 被编程为在 30 秒阻滞中交替开/关后,使用阻滞设计进行 BOLD MRI。利用表面电生理记录触发扫描仪检测 DBS 周期。共获得 9 次运行,并使用一般线性模型进行分析。 结果: 活跃的蚂蚁刺激在大脑的几个区域内产生激活,包括丘脑、双侧前扣带回和后扣带回皮质、楔前叶、内侧前额叶皮质、杏仁核、腹侧被盖区、海马、纹状体和右角回。 结论: 利用 block-design BOLD MRI,我们能够显示 ANT DBS 导致的广泛激活。显示了与默认模式和边缘网络的多个区域的重叠,表明这些节点可能通过 ANT DBS 调节癫痫发作控制的效果。

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DOI:10.1007/s11011-020-00536-z
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影响因子:4.30
发表时间:2020-01-24
来源期刊:Experimental neurology
DOI:10.1016/j.expneurol.2020.113212
作者列表:["Bertrand SJ","Zhang Z","Patel R","O'Ferrell C","Punjabi NM","Kudchadkar SR","Kannan S"]

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影响因子:1.52
发表时间:2020-01-27
来源期刊:World neurosurgery
DOI:10.1016/j.wneu.2020.01.108
作者列表:["Middlebrooks EH","Lin C","Okromelidze L","Lu CQ","Tatum WO","Wharen RE Jr","Grewal SS"]

METHODS:BACKGROUND:Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a recently approved therapy for patients with drug-resistant epilepsy. To date, there is a poor understanding of the mechanism of action and lack of in vivo biomarkers. We propose a method for investigating the in vivo stimulation effects using blood-oxygen-level dependent (BOLD) MRI and present the brain activation pattern associated with ANT DBS. METHODS:Two patients undergoing ANT DBS for epilepsy underwent BOLD MRI using a block design after the DBS was programmed to alternate ON/OFF in 30 second blocks. The scanner was triggered utilizing surface electrophysiological recording to detect the DBS cycle. Nine total runs were obtained and were analyzed using a general linear model. RESULTS:Active ANT stimulation produced activation within several areas of the brain, including the thalamus, bilateral anterior cingulate and posterior cingulate cortex, precuneus, medial prefrontal cortex, amygdala, ventral tegmental area, hippocampus, striatum, and right angular gyrus. CONCLUSIONS:Utilizing block-design BOLD MRI, we were able to show widespread activation resulting from ANT DBS. Overlap with multiple areas of both the default mode and limbic networks was shown suggesting that these nodes may modulate the effect of seizure control with ANT DBS.

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