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Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.

创伤后应激障碍概念水平恐惧泛化的神经相关因素。

  • 影响因子:6.22
  • DOI:10.1038/s41386-020-0661-8
  • 作者列表:"Morey RA","Haswell CC","Stjepanović D","Mid-Atlantic MIRECC Workgroup.","Dunsmoor JE","LaBar KS
  • 发表时间:2020-03-28
Abstract

:Posttraumatic stress disorder (PTSD) may develop when mechanisms for making accurate distinctions about threat relevance have gone awry. Generalization across conceptually related objects has been hypothesized based on clinical observation in PTSD, but the neural mechanisms remain unexplored. Recent trauma-exposed military veterans (n = 46) were grouped into PTSD (n = 23) and non-PTSD (n = 23). Participants learned to generalize fear across conceptual categories (animals or tools) of semantically related items that were partially reinforced by shock during functional magnetic resonance imaging. Conditioned fear learning was quantified by shock expectancy and skin conductance response (SCR). Relative to veteran controls, PTSD subjects exhibited a stronger neural response associated with fear generalization to the reinforced object category in the striatum, anterior cingulate cortex, amygdala, occipitotemporal cortex, and insula (Z > 2.3; p < 0.05; whole-brain corrected). Based on SCR, both groups generalized the shock contingency to the reinforced conceptual category, but learning was not significantly different between groups. We found that PTSD was associated with an enhanced neural response in fronto-limbic, midline, and occipitotemporal regions to a learned representation of threat that is based on previously established conceptual knowledge of the relationship between basic-level exemplars within a semantic category. Behaviorally, veterans with PTSD were somewhat slower to differentiate threat and safety categories as compared with trauma-exposed veteran controls owing in part to an initial overgeneralized behavioral response to the safe category. These results have implications for understanding how fear spreads across semantically related concepts in PTSD.

摘要

: 当准确区分威胁相关性的机制出错时,创伤后应激障碍 (PTSD) 可能会发展。基于 PTSD 的临床观察,假设跨概念相关对象的泛化,但神经机制仍未被探索。近期暴露于创伤的退伍军人 (n = 46) 分为 PTSD (n = 23) 和非 PTSD (n = 23)。参与者学会了在功能磁共振成像过程中通过休克部分强化的语义相关项目的概念类别 (动物或工具) 中概括恐惧。条件性恐惧学习通过休克期望和皮肤传导反应 (SCR) 进行量化。相对于退伍军人对照组,PTSD 受试者在纹状体、前扣带皮层、杏仁核、枕颞皮层中表现出与恐惧泛化相关的更强的神经反应。和脑岛 (z> 2.3; P <0.05; 全脑校正)。基于 SCR,两组均将休克偶然性推广到强化的概念类别,但学习在组间无显著差异。我们发现,创伤后应激障碍与额边缘、中线和枕颞区的神经反应增强有关,这种反应是基于对语义范畴内的基本级别范例之间关系的先前建立的概念性知识而形成的对威胁的习得表征。行为上,与创伤暴露的退伍军人对照相比,PTSD 退伍军人区分威胁和安全类别的速度稍慢,部分原因是对安全类别的初始过度泛化行为反应。这些结果对理解恐惧如何在 PTSD 中跨语义相关概念传播有影响。

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影响因子:5.83
发表时间:2020-01-22
DOI:10.1523/JNEUROSCI.0786-19.2019
作者列表:["Torretta S","Rampino A","Basso M","Pergola G","Di Carlo P","Shin JH","Kleinman JE","Hyde TM","Weinberger DR","Masellis R","Blasi G","Pennuto M","Bertolino A"]

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影响因子:6.22
发表时间:2020-01-17
DOI:10.1038/s41386-020-0614-2
作者列表:["Chadha R","Meador-Woodruff JH"]

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