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Effect of Muscle Mass Loss After Esophagectomy on Prognosis of Oesophageal Cancer.

食管切除术后肌肉质量损失对食管癌预后的影响。

  • 影响因子:1.90
  • DOI:10.21873/anticanres.14192
  • 作者列表:"Shimoda Y","Yamada T","Komori K","Watanabe H","Osakabe H","Kano K","Fujikawa H","Hayashi T","Cho H","Shiozawa M","Yoshikawa T","Morinaga S","Ota Y","Katsumata K","Tsuchida A","Ogata T","Oshima T
  • 发表时间:2020-04-01
Abstract

BACKGROUND/AIM:To assess the prognostic effect of muscle loss after esophagectomy and before discharge. PATIENTS AND METHODS:This study retrospectively analysed 159 consecutive patients with oesophageal and gastroesophageal junction cancer who underwent esophagectomy between August 2011 and October 2015. Body composition was evaluated one week before surgery and at discharge using a bioelectrical impedance analyser. RESULTS:The median rate of muscle mass loss (RMML) was 4.38% (range=-3.3 to +18.8). Patients with increased RMML had significantly poorer outcomes of overall survival than those with decreased RMML (p=0.015). On multivariate analysis, RMML [≥4.38, hazard ratio (HR)=2.033, 95% confidence interval (CI)=1.018-5.924, p=0.044) and pathological tumour depth (≥2, HR=3.099, 95%CI=1.339-7.172, p=0.008) were selected as independent prognostic factors. CONCLUSION:RMML after esophagectomy is indicative of poor prognosis in patients with esophageal cancer.

摘要

背景/目的: 评估食管切除术后和出院前肌肉丢失的预后效果。 患者和方法: 本研究回顾性分析了 2011 年 8 月至 2015 年 10 月期间接受食管切除术的 159 例连续食管和胃食管连接部癌患者。术前 1 周和出院时使用生物电阻抗分析仪评估身体成分。 结果: 肌肉质量损失的中位率 (RMML) 为 4.38% (范围 =-3.3 至 + 18.8)。与RMML降低的患者相比,RMML升高的患者总生存期的结局显著较差 (p = 0.015)。在多变量分析上,RMML [≥ 4.38,危险比 (HR)= 2。033,95% 置信区间 (CI)= 1.018-5.9 2 4,p = 0.044) 和病理肿瘤深度 (≥ 2,HR = 3.099,95% CI = 1.339-7.17 2,p = 0.008) 作为独立预后因素。 结论: 食管癌术后RMML提示患者预后不良。

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