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通过循环肿瘤DNA的低深度全基因组测序阐明前列腺癌治疗期间的行为
Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA
From：Eur Urol Date：2021-08-20
IF：20.1 类型：临床
Read：431 Author：Semini Sumanasuriya
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晚期胃癌和胃食管交界癌的生物标志物靶向治疗：一个新兴的模式
Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm
From：NAT REV CLIN ONCOL Date：2021-08-15
IF：66.7 类型：综述
Read：407 Author：Nakamura Y
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CTLA-4反馈通路阻断后瘤内Treg细胞扩增
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
From：Cell Date：2021-07-22
IF：41.6 类型：基础
Read：349 Author：Marangoni F
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Tim-4+ 体腔驻留巨噬细胞损害CD8+ T细胞抗肿瘤免疫
Tim-4+ cavity-resident macrophages impair antitumor CD8+ T cell immunity
From：Cancer Cell Date：2021-07-12
IF：31.7 类型：基础
Read：186 Author：Chow A
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肠道微生物群特征与CTLA-4和PD-1联合阻断的毒性相关
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
From：Nat Med Date：2021-07-08
IF：53.4 类型：基础
Read：186 Author：Andrews MC
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肿瘤恶病质中胰高血糖素通过影响REV-ERBα稳定性调节肝糖生成
Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer-associated cachexia
From：Sci Adv Date：2021-06-25
IF：14.1 类型：基础
Read：181 Author：Amandine Verlande
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口服牛乳来源胞外囊泡可诱导原发肿瘤衰老但加速转移
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
From：Nat Commun Date：2021-06-24
IF：14.9 类型：基础
Read：175 Author：Monisha Samuel
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伊沙妥昔单抗、卡菲佐米和地塞米松治疗复发性多发性骨髓瘤（IKEMA）：一项多中心、开放标签、随机3期试验
Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial
From：Lancet Date：2021-06-19
IF：79.3 类型：临床
Read：181 Author：Moreau P
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CAR T细胞在癌症治疗中的免疫原性
Immunogenicity of CAR T cells in cancer therapy
From：Nat Rev Clin Oncol Date：2021-06-18
IF：66.7 类型：综述
Read：489 Author：Dimitrios L. Wagner
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基于血液的液体活检的定量和定性分析为前列腺癌的临床决策提供信息
Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer
From：EUROPEAN UROLOGY Date：2021-06-15
IF：20.1 类型：综述
Read：202 Author：Casanova-Salas I
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戈沙妥组单抗，一种Trop-2定向的抗体-药物偶联物，用于治疗上皮癌患者：I/II期IMMU-132-01篮式试验的最终安全性和有效性结果
Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial
From：ANNALS OF ONCOLOGY Date：2021-06-15
IF：33.0 类型：临床
Read：128 Author：Bardia A
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小细胞肺癌：免疫治疗后的罕见疾病
Small cell lung cancer: a slightly less orphan disease after immunotherapy
From：Ann Oncol Date：2021-06-15
IF：33.0 类型：综述
Read：232 Author：Remon J
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新辅助免疫治疗III期黑色素瘤后病理学缓解和肿瘤灶位组织病理学特征与生存率相关
Pathological response and tumour bed histopathological features correlate with survival following neoadjuvant immunotherapy in stage III melanoma
From：Ann Oncol Date：2021-06-06
IF：33.0 类型：临床
Read：338 Author：R. V. Rawson
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PIK3CA和CCM突变通过一种类似癌症的机制刺激海绵状血管瘤
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
From：Nature Date：2021-06-05
IF：49.9 类型：基础
Read：385 Author：Aileen A. Ren
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ARAF突变赋予黑色素瘤对RAF抑制剂belvarafenib的耐药性
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma
From：Nature Date：2021-06-01
IF：50.0 类型：基础
Read：163 Author：Ivana Yen
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纳武单抗用于二线治疗复发性小细胞肺癌：CheckMate 331
Second-line nivolumab in relapsed small-cell lung cancer: CheckMate 331
From：ANN ONCOL Date：2021-05-15
IF：33.0 类型：临床
Read：210 Author：Spigel DR
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切尔诺贝利事故后甲状腺乳头状癌的辐射相关基因组特征
Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
From：Science Date：2021-05-14
IF：47.7 类型：基础
Read：199 Author：Morton LM
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单细胞组学和靶向治疗时代结直肠癌干细胞的临床意义
Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted Therapies
From：Gastroenterology Date：2021-05-06
IF：22.7 类型：综述
Read：366 Author：Markus H. Frank
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微卫星不稳定性高或错配修复缺陷的转移性结直肠癌患者接受一线派姆单抗VS化疗的健康相关生活质量（KENYEN-177）：一项开放标签、随机、3期试验
Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177): an open-label, randomised, phase 3 trial
From：LANCET ONCOL Date：2021-05-06
IF：41.3 类型：临床
Read：205 Author：Thierry Andre
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小分子抑制剂METTL治疗疗髓系白血病
Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia
From：Nature Date：2021-05-05
IF：50.0 类型：基础
Read：267 Author：Eliza Yankova
