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davoceticept（ALPN-202），一种PD-L1依赖性CD28共刺激剂和双重PD-L1/CTLA-4抑制剂，用于晚期实体瘤（NEON-1和NEON-2）的单药治疗和与派姆单抗联合治疗的I期研究
Phase I studies of davoceticept（ALPN-202），a PD-L1-dependent CD28 co-stimulator and dual PD-L1/CTLA-4 inhibitor, as monotherapy and in combination with pembrolizumab in advanced solid tumors（NEON-1 and NEON-2）
From：J Immunother Cancer Date：2024-08-03
IF：10.3 类型：临床
Read：25 Author：Diwakar Davar
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罗格列酮和曲美替尼在肌肉浸润性膀胱癌小鼠模型中表现出有效的抗肿瘤活性
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer
From：Nat Commun Date：2024-08-02
IF：14.7 类型：基础
Read：9 Author：Sakina A Plumber
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吉西他滨、奥沙利铂和白蛋白结合型紫杉醇作为晚期胆道癌患者一线治疗的多中心I/II期试验
Multicenter phase I/II trial of gemcitabine, oxaliplatin and nab-paclitaxel as first-line treatment for patients with advanced biliary tract cancer
From：Eur J Cancer Date：2024-08-01
IF：7.6 类型：临床
Read：8 Author：Tiziana Pressiani
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HER-2阳性胃癌:目前的靶向治疗
HER-2 positive gastric cancer: Current targeted treatments
From：Int J Biol Macromol Date：2024-08-01
IF：7.7 类型：综述
Read：15 Author：Rama Rao Malla
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内质网应激相关XBP1s/miR-22/SIRT1轴在急性髓系白血病细胞凋亡和化疗应答中的关键作用
Pivotal role of the endoplasmic reticulum stress-related XBP1s/ miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy
From：Leukemia Date：2024-08-01
IF：12.8 类型：基础
Read：6 Author：Céline Philippe
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评估围手术期改良FOLFIRINOX在可切除胰腺导管腺癌患者中的疗效的非随机对照试验
Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer A Nonrandomized Controlled Trial
From：JAMA Oncol Date：2024-08-01
IF：22.5 类型：临床
Read：2 Author：Michael Cecchini
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对比艾萨妥昔单抗+卡非佐米+地塞米松与卡非佐米+地塞米松治疗复发性多发性骨髓瘤（IKEMA）：一项Ⅲ期随机对照试验的总生存期分析
Isatuximab plus carfilzomib–dexamethasone versus carfilzomib–dexamethasone in patients with relapsed multiple myeloma (IKEMA): overall survival analysis of a phase 3, randomised, controlled trial
From：Lancet Haematol Date：2024-07-24
IF：15.4 类型：临床
Read：2 Author：Kwee Yong
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TSG-6+ 癌症相关成纤维细胞调节骨髓细胞反应并削弱胰腺癌中免疫检查点治疗的抗肿瘤反应
TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer
From：Nat Commun Date：2024-07-10
IF：14.7 类型：基础
Read：2 Author：Swetha Anandhan
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多发性骨髓瘤的生物学复发：一项在西班牙进行的真实世界研究环境下的结局与治疗策略
Biological relapse in multiple myeloma: Outcome and treatment strategies in a Spanish real‐world setting
From：Hemasphere Date：2024-07-04
IF：7.6 类型：临床
Read：2 Author：Adrián Alegre
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粪便免疫化学检测筛查与结直肠癌死亡风险
Fecal Immunochemical Test Screening and Risk of Colorectal Cancer Death
From：JAMA Netw Open Date：2024-07-03
IF：10.5 类型：临床
Read：4 Author：Chyke A Doubeni
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CTNND1通过影响细胞间相互作用参与早发性胃癌的种系易感性
CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
From：Gastric Cancer Date：2024-07-01
IF：5.9 类型：基础
Read：8 Author：Cristina Herrera-Pariente
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用于检测和治疗结直肠癌的工程细菌疗法
Engineered bacterial therapeutics for detecting and treating CRC
From：Trends Cancer Date：2024-07-01
IF：14.2 类型：综述
Read：6 Author：Nicole Siguenza
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肿瘤抑制因子p53的基因调控—组学时代
Gene regulation by the tumor suppressor p53 - The omics era
From：Biochim Biophys Acta Rev Cance Date：2024-07-01
IF：9.7 类型：综述
Read：40 Author：Martin Fischer
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促血管生成的人类卵巢肿瘤微环境芯片评估微循环中血小板的病理生理学
Angiogenesis-Enabled Human Ovarian Tumor Microenvironment-Chip Evaluates Pathophysiology of Platelets in Microcirculation
From：Adv Healthc Mater Date：2024-07-01
IF：10.0 类型：基础
Read：2 Author：Lopamudra D Ghosh
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Nrf2E79Q突变体增强致癌Ras角化细胞和皮肤肿瘤的亚群的促进和进展
Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors
From：Redox Biol Date：2024-06-28
IF：10.7 类型：基础
Read：3 Author：John G Witherspoon
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转移性结直肠癌的血清小RNAs可预测对化疗的应答并识别高危患者
Serum small RNAs in metastatic colorectal cancer predict response to chemotherapy and characterize high-risk patients
From：MOL CANCER Date：2024-06-27
IF：27.7 类型：基础
Read：2 Author：Robin Mjelle
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基于抗体纳米颗粒偶联物的非小细胞肺癌靶向免疫治疗
Antibody nanoparticle conjugate–based targeted immunotherapy for non–small cell lung cancer
From：Sci Adv Date：2024-06-14
IF：11.7 类型：基础
Read：2 Author：Tanmoy Saha
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一项随机试验中伊马替尼辅助治疗的胃肠间质瘤破裂患者的生存率
Survival of patients with ruptured gastrointestinal stromal tumour treated with adjuvant imatinib in a randomised trial
From：Br J Cancer Date：2024-06-11
IF：6.3 类型：临床
Read：16 Author：Heikki Joensuu
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体内启动的双特异性T细胞接合剂的结构改变增强了对肾细胞癌的疗效
Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma
From：J Immunother Cancer Date：2024-06-04
IF：10.3 类型：基础
Read：5 Author：Ryan P O'Connell
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术前化疗后可切除胰腺癌患者的病理完全缓解率
Pathological Complete Response in Patients With Resected Pancreatic Adenocarcinoma After Preoperative Chemotherapy
From：JAMA Netw Open Date：2024-06-03
IF：10.5 类型：临床
Read：10 Author：Thomas F Stoop
