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皮肤鳞状细胞癌
Squamous-Cell Carcinoma of the Skin
From：N Engl J Med Date：2023-06-15
IF：158.4 类型：综述
Read：20 Author：Ashley Wysong
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德曲妥珠单抗与医生选择治疗HER2阳性转移性乳腺癌（DESTINY-Breast02）：一项随机、非盲、多中心、3期试验
Trastuzumab deruxtecan versus treatment of physician’s choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): a randomised, open-label, multicentre, phase 3 trial
From：Lancet Date：2023-05-27
IF：168.9 类型：临床
Read：27 Author：Fabrice André
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Sirtuin 6是整合应激反应和抵抗转录周期蛋白依赖性激酶抑制所必需的
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases
From：Sci Transl Med Date：2023-05-03
IF：17.0 类型：基础
Read：16 Author：Nithya Kartha
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GSDMB异构体和蛋白酶酶切过程差异化调控肿瘤细胞的焦亡和线粒体损伤
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
From：Cell Death Differ Date：2023-05-01
IF：12.4 类型：基础
Read：64 Author：Sara S Oltra
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图卡替尼联合曲妥珠单抗治疗化疗难治性、HER2阳性、RAS野生型不可切除或转移性结直肠癌（MOUNTAINEER）：一项多中心、非盲、2期研究
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study
From：Lancet Oncol Date：2023-05-01
IF：51.1 类型：临床
Read：12 Author：John H Strickler
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自噬通过调节胰腺癌中的铁稳态来支持线粒体代谢
Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer
From：Sci Adv Date：2023-04-21
IF：13.6 类型：基础
Read：43 Author：Subhadip Mukhopadhyay
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RNA结合蛋白SYNCRIP维持造血干细胞和祖细胞的蛋白稳态和自我更新
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
From：Nat Commun Date：2023-04-21
IF：16.6 类型：基础
Read：9 Author：Florisela Herrejon Chavez
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比较帕尼单抗与贝伐珠单抗分别联合标准一线化疗治疗RAS野生型左侧mCRC的总生存期：一项随机临床研究
Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-Sided Metastatic Colorectal Cancer: A Randomized Clinical Trial
From：JAMA Date：2023-04-18
IF：120.7 类型：临床
Read：15 Author：Jun Watanabe
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前列腺癌筛查
Screening for Prostate Cancer
From：N Engl J Med Date：2023-04-13
IF：158.4 类型：综述
Read：11 Author：Paul F Pinsky
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可转化的载药氧化铁纳米团导致小鼠黑色素瘤对单克隆抗体免疫治疗增敏
Translatable Drug-Loaded Iron Oxide Nanophore Sensitizes Murine Melanoma Tumors to Monoclonal Antibody Immunotherapy
From：ACS Nano Date：2023-04-11
IF：17.0 类型：基础
Read：16 Author：Evan P Stater
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亚油酸增强CD8+ T细胞代谢适应性和抗肿瘤免疫
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
From：Cell Metab Date：2023-04-04
IF：28.9 类型：基础
Read：29 Author：Carina B Nava Lauson
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急性流感感染通过改变肿瘤微环境来促进肺肿瘤的生长
Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment
From：Cancer Immunol Res Date：2023-04-03
IF：10.1 类型：基础
Read：58 Author：Irati Garmendia
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免疫相关基因表达特征与肿瘤浸润淋巴细胞对早期ERBB2/HER2阳性乳腺癌的预后及预测价值：CALGB 40601与PAMELA试验的相关分析
Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer: A Correlative Analysis of the CALGB 40601 and PAMELA Trials
From：JAMA Oncol Date：2023-04-01
IF：28.4 类型：临床
Read：22 Author：Aranzazu Fernandez-Martinez
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形状的重要意义：可生物降解、各向异性纳米粒子人工抗原呈递细胞用于癌症免疫治疗
Shape matters: Biodegradable anisotropic nanoparticle artifificial antigen presenting cells for cancer immunotherapy
From：Acta Biomater Date：2023-04-01
IF：9.7 类型：基础
Read：26 Author：Elana Ben-Akiva
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肿瘤选择性腺病毒enadenotucirev联合纳武单抗治疗晚期/转移性上皮癌的安全性和有效性：一项I期临床试验（SPICE）
Safety and efficacy of the tumor-selective adenovirus enadenotucirev, in combination with nivolumab, in patients with advanced/metastatic epithelial cancer: a phase I clinical trial (SPICE)
From：J Immunother Cancer Date：2023-04-01
IF：10.8 类型：临床
Read：7 Author：Marwan Fakih
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霍奇金淋巴瘤患者的放疗和丙卡巴肼剂量与结直肠癌风险的关系
Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer Among Survivors of Hodgkin Lymphoma
From：JAMA Oncol Date：2023-04-01
IF：28.4 类型：临床
Read：8 Author：Yvonne M Geurts
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可注射水凝胶纳米复合材料用于脑肿瘤术后治疗的穿透性和持续性药物递送
Penetrative and Sustained Drug Delivery Using Injectable Hydrogel Nanocomposites for Postsurgical Brain Tumor Treatment
From：ACS Nano Date：2023-03-28
IF：17.0 类型：基础
Read：16 Author：Taegyu Kang
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整合肿瘤来源的外泌体和聚（酰胺-胺）树状高聚物的混合纳米颗粒系统：有效基因递送平台的意义
Hybrid Nanoparticle System Integrating Tumor-Derived Exosomes and Poly(amidoamine) Dendrimers: Implications for an Effective Gene Delivery Platform
From：Chem Mater Date：2023-03-24
IF：8.6 类型：基础
Read：7 Author：Ashita Nair
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体内化学成像的个性化肿瘤治疗：肿瘤氧的光声测绘可预测放疗疗效
Personalized Oncology by In Vivo Chemical Imaging: Photoacoustic Mapping of Tumor Oxygen Predicts Radiotherapy Efficacy
From：ACS Nano Date：2023-03-14
IF：17.1 类型：基础
Read：24 Author：Janggun Jo
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在BRCA缺陷癌症模型中，聚合酶θ抑制激活cGAS-STING通路并与免疫检查点阻断起协同作用
Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer
From：Nat Commun Date：2023-03-13
IF：16.6 类型：基础
Read：22 Author：Jeffrey Patterson-Fortin
