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Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non-small-cell lung cancer: A case-control study.

第 10 号染色体多态性 rs1903858 缺失的磷酸酶和张力同源物,而不是血清水平与非小细胞肺癌风险的相关性: 一项病例对照研究。

  • 影响因子:1.46
  • DOI:10.1002/jcla.23328
  • 作者列表:"Liang Z","Tang Y","Li H","Xie Y","Zhan L
  • 发表时间:2020-06-15
Abstract

BACKGROUND:To investigate the association between phosphatase and tension homologue deleted on chromosome ten (PTEN) gene polymorphisms and non-small-cell lung cancer (NSCLC) and further identify whether these polymorphisms influence serum PTEN levels. METHODS:A total of 152 NSCLC patients and 124 healthy controls were included in the study. PTEN gene rs11202586 (T > C) and rs1903858 (A > G) polymorphisms were detected using the multiple single-base extension technique (SNaPshot). The serum PTEN levels were determined using an enzyme-linked immunosorbent assay (ELISA) kit. RESULTS:The rs1903858 AG, GG genotypes, and G allele were associated with a higher risk of NSCLC (odds ratio (OR) =2.079, 95% confidence interval (CI) = 1.087-3.974, P = .027; OR = 1.897, 95%CI = 1.053-3.419, P = .033; OR = 1.505, 95%CI = 1.065-2.126, P = .020). Stratified analysis reveal that the rs1903858 GG genotype and G allele were associated with an increased risk of squamous cell carcinoma (SCC) (OR = 3.226, 95%CI = 1.075-9.678, P = .037; OR = 1.873, 95%CI = 1.092-3.212, P = .023). Among smokers, the rs1903858 G allele carriers have an increased risk of NSCLC (OR = 1.916, 95%CI = 1.023-3.589, P = .042), but a decreased risk of NSCLC was found with the AT haplotype. With respect to the serum PTEN levels, no significant difference was noted between NSCLC patients and healthy controls in this study. CONCLUSIONS:The study indicated that the rs1903858 gene polymorphism is associated with increased risk of NSCLC, particularly in SCC and smoker, and the haplotype AT was a protective factor for NSCLC. The serum PTEN levels were not associated with NSCLC.

摘要

背景: 探讨第 10 号染色体缺失的磷酸酶和张力同源物 (PTEN) 基因多态性与非小细胞肺癌 (NSCLC) 的相关性。并进一步鉴定这些多态性是否影响血清 PTEN 水平。 方法: 共有 152 例 NSCLC 患者和 124 例健康对照者纳入研究。采用多重单碱基延伸技术 (SNaPshot) 检测 PTEN 基因 rs11202586 (T > C) 和 rs1903858 (A > G) 多态性。采用酶联免疫吸附试验 (ELISA) 试剂盒测定血清 PTEN 水平。 结果: rs1903858 AG 、 GG 基因型和 G 等位基因与 NSCLC 的高风险相关 (比值比 (OR) = 2.079,95% 可信区间 (CI) = 1.087-3.974, P =。027; OR = 1.897,95% CI = 1.053-3.419,P = .033; OR = 1.505,95% CI = 1.065-2.126,P = .020)。分层分析显示,rs1903858 GG 基因型和 G 等位基因与鳞状细胞癌 (SCC) 风险增加相关 (OR = 3.226,95% CI = 1.075-9.678,P = .037; OR = 1.873,95% CI = 1.092-3.212,P = .023)。在吸烟者中,rs1903858g 等位基因携带者患 NSCLC 的风险增加 (OR = 1.916,95% CI = 1.023-3.589,P = .042),但发现 AT 单倍型降低了 NSCLC 的风险。关于血清 PTEN 水平,在本研究中未观察到 NSCLC 患者和健康对照者之间存在显著差异。 结论: rs1903858 基因多态性与 NSCLC 发病风险增加有关,尤其是在 SCC 和吸烟者中,单倍型 AT 是 NSCLC 发病的保护因素。血清 PTEN 水平与 NSCLC 无关。

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影响因子:1.84
发表时间:2020-01-01
来源期刊:Oncology letters
DOI:10.3892/ol.2019.11149
作者列表:["Das SK","Huang YY","Li B","Yu XX","Xiao RH","Yang HF"]

METHODS::The aim of the present study was to compare the safety and efficacy of cryoablation (CA) and microwave ablation (MWA) as treatments for non-small cell lung cancer (NSCLC). Patients with stage IIIB or IV NSCLC treated with CA (n=45) or MWA (n=56) were enrolled in the present study. The primary endpoint was progression-free survival (PFS); the secondary endpoints included overall survival (OS) time and adverse events (AEs). The median PFS times between the two groups were not significantly different (P=0.36): CA, 10 months [95% confidence interval (CI), 7.5-12.4] vs. MWA, 11 months (95% CI, 9.5-12.4). The OS times between the two groups were also not significantly different (P=0.07): CA, 27.5 months (95% CI, 22.8-31.2 months) vs. MWA, 18 months (95% CI, 12.5-23.5). For larger tumors (>3 cm), patients treated with MWA had significantly longer median PFS (P=0.04; MWA, 10.5 months vs. CA, 7.0 months) and OS times (P=0.04; MWA, 24.5 months vs. CA, 14.5 months) compared patients treated with CA. However, for smaller tumors (≤3 cm), median PFS (P=0.79; MWA, 11.0 months vs. CA, 13.0 months) and OS times (P=0.39; MWA, 30.0 months vs. CA, 26.5 months) between the two groups did not differ significantly. The incidence rates of AEs were similar in the two groups (P>0.05). The number of applicators, tumor size and length of the lung traversed by applicators were associated with a higher risk of pneumothorax and intra-pulmonary hemorrhage in the two groups. Treatment with CA resulted in significantly less intraprocedural pain compared with treatment with MWA (P=0.001). Overall, the present study demonstrated that CA and MWA were comparably safe and effective procedures for the treatment of small tumors. However, treatment with MWA was superior compared with CA for the treatment of large tumors.

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DOI:10.1016/j.annonc.2019.10.022
作者列表:["Mazieres J","Cropet C","Montané L","Barlesi F","Souquet PJ","Quantin X","Dubos-Arvis C","Otto J","Favier L","Avrillon V","Cadranel J","Moro-Sibilot D","Monnet I","Westeel V","Le Treut J","Brain E","Trédaniel J","Jaffro M","Collot S","Ferretti GR","Tiffon C","Mahier-Ait Oukhatar C","Blay JY"]

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