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Beneficial effects of physical activity on depressive and OCD-like behaviors in the male offspring of morphine-abstinent rats.

体力活动对吗啡戒断大鼠雄性后代抑郁和强迫症样行为的有益影响。

  • 影响因子:3.15
  • DOI:10.1016/j.brainres.2020.146908
  • 作者列表:"Nouri Zadeh-Tehrani S","Sadat-Shirazi MS","Akbarabadi A","Aghadokht-Mamaghani A","Soltani H","Mokri A","Zarrindast MR
  • 发表时间:2020-10-01
Abstract

:The role of parental morphine exposure before gestation on mood disorder in the offspring was well described. Besides, physical activity can improve the symptoms of mood disorders. So, the current study aimed to investigate the role of physical activity on depressive and OCD-like behaviors induced by parental morphine exposure. 40 male and 40 female Wistar rats (60-days old) received morphine for consecutive 10 days and were drug-free for 10 days. They were prepared for mating either with a morphine-abstinent or with a drug-naïve rat. The adult male offspring were divided into two groups as follows: (1) those that were subjected to treadmill exercise for three weeks (3-days each week), and (2) those without exercise. Also, the offspring were subjected to forced swimming and marble-burying tests. The levels of 5-HT3 receptor (R), D1, and D2 dopamine receptor (DR) were evaluated as well as the level of monoamine oxidase-B (MAO-B) in the prefrontal cortex (PFC). Results showed that exercise improved depressive and OCD-like behaviors in the offspring of morphine-abstinent rats. Western blotting data revealed that the levels of 5-HT3R, D1DR, D2DR, and MAO-B in the PFC increased in the offspring of morphine-abstinent rats compared to the control. However, it was shown that treadmill exercise decreases the levels of 5-HT3R, MAO-B, and D2DR. Morphine exposure, even before conception, could affect the behaviors in the offspring. Besides, the molecular changes were also detected in the brain. We found that mild physical activity might modulate OCD and depressive-like behavior in the offspring of morphine-abstinent rats by decreasing the levels of 5-HT3R, D2DR, and MAO-B located in the PFC.

摘要

: 很好地描述了妊娠前父母吗啡暴露对后代情绪障碍的作用。此外,身体活动可以改善情绪障碍的症状。因此,本研究旨在探讨体力活动对父母吗啡暴露诱导的抑郁和强迫症样行为的作用。40 只雄性和 40 只雌性 Wistar 大鼠 (60 日龄) 接受吗啡连续 10 天,10 天无药。他们准备与吗啡戒断者或药物初治大鼠交配。成年雄性后代分为以下两组 :( 1) 进行为期三周的踏车运动 (每周 3 天),和 (2) 那些没有锻炼的人。此外,后代还接受了强迫游泳和大理石掩埋试验。评估 5-HT3 受体 (R) 、 D1 和 D2 多巴胺受体 (DR) 水平以及单胺氧化酶-B (MAO-B) 水平在前额叶皮层 (PFC)。结果表明,运动改善了吗啡戒断大鼠子代的抑郁和强迫症样行为。Western blotting 数据显示,与对照组相比,吗啡戒断大鼠子代 PFC 中 5-HT3R 、 D1DR 、 D2DR 和 MAO-B 水平升高。然而,结果表明,跑台运动降低了 5-HT3R 、 MAO-B 和 D2DR 的水平。吗啡暴露,即使在受孕之前,也会影响后代的行为。此外,在大脑中也检测到分子变化。我们发现轻度体力活动可能通过降低位于 PFC 的 5-HT3R 、 D2DR 和 MAO-B 水平来调节吗啡戒断大鼠后代的强迫症和抑郁样行为。

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影响因子:5.83
发表时间:2020-01-22
DOI:10.1523/JNEUROSCI.0786-19.2019
作者列表:["Torretta S","Rampino A","Basso M","Pergola G","Di Carlo P","Shin JH","Kleinman JE","Hyde TM","Weinberger DR","Masellis R","Blasi G","Pennuto M","Bertolino A"]

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影响因子:6.22
发表时间:2020-01-17
DOI:10.1038/s41386-020-0614-2
作者列表:["Chadha R","Meador-Woodruff JH"]

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