The urinary β_2 microglobulin-creatinine ratio is inversely associated with lumbar spine bone mineral density in the elderly Chinese males
中国老年男性尿 β 2 微球蛋白-肌酐比值与腰椎骨密度呈负相关
- 作者列表："Zhou, Xun","Hong, Wei","Chen, Weijun","Feng, Xinhui","Zhang, Zhenxing","Zhang, Xiaoli","Fu, Chensheng","Xiao, Jing","Ye, Zhibin
Summary Renal tubule cells play a pivotal role in maintaining bone homeostasis. Hence, renal tubular function may be associated with bone mineral density. Our study found that urinary β_2 microglobulin-creatinine ratio (UBCR) levels correlated negatively with lumbar spine bone mineral density (BMD) and T and Z values, and may be a marker for osteoporosis in Chinese elderly male adults. Purpose To study the association of UBCR levels with BMD and the predictive value of UBCR for osteoporosis in elderly Chinese male adults. Methods A cross-sectional study of 149 (65 to 85 years, 69.7 ± 4.6) Chinese male adults who underwent health checkups in Huadong Hospital in Shanghai China was conducted. BMD was measured by dual-energy X-ray absorptiometry. The clinical variables and BMD of the participants in the low UBCR group (B1, UBCR < 300 μg/g) and the high UBCR group (B2, UBCR ≥ 300 μg/g) were compared. Associations between UBCR with clinical variables and BMD were analyzed by Pearson’s correlation coefficient and multiple regression analysis. BMD and T and Z values were compared between the B1 and B2 groups. The odds ratios (ORs) for dose-dependent increases in osteoporosis between B1 and B2 were analyzed by binary logistic regression analysis. The area under the receiver operating characteristic (ROC) curve was used to analyze the capacity of UBCR to predict osteoporosis. Results UBCR was significantly higher in the osteoporosis group. After adjusting for multiple confounders, UBCR levels correlated negatively with BMD and T and Z values of the lumbar spine. Lumbar spine BMD and T and Z values were significantly lower in the B2 UBCR group than in the B1 UBCR group. Compared with the B1 participants, the ORs for “osteoporosis” were 12.401 times higher in B2 participants ( P = 0.005) by binary logistic regression analysis after adjusting for potential confounders. The UBCR index (cutoff = 362.48 μg/g) had a sensitivity of 78.6% and a specificity of 68.7% for identifying osteoporosis, with an area under the ROC curve of 0.760. Conclusions These results suggest that UBCR levels correlate negatively with lumbar spine BMD and T and Z values and may serve as a marker for osteoporosis in Chinese elderly male adults.
小结肾小管细胞在维持骨稳态中起着举足轻重的作用。因此，肾小管功能可能与骨密度有关。我们的研究发现，尿 β 2 微球蛋白-肌酐比值 (UBCR) 水平与腰椎骨密度 (BMD) 及 T 、 Z 值呈负相关。并可能是中国老年男性成人骨质疏松的标志。目的探讨中国老年男性骨密度 (BMD) 与 UBCR 水平的关系及其对骨质疏松的预测价值。方法采用横断面研究方法，对 149 名 (65 ~ 85 岁，69.7 ± 4.6) 在上海市华东医院进行健康体检的中国成年男性进行研究。采用双能 x线骨密度仪测量 BMD。低 UBCR 组 (B1，UBCR <300 μ g/g) 和高 UBCR 组 (B2，UBCR ≥ 300 μ g/g) 参与者的临床变量和 BMD 进行了比较。通过 Pearson 相关系数和多元回归分析 UBCR 与临床变量和 BMD 的相关性。比较 B1 组和 B2 组的 BMD 及 T 和 Z 值。采用二元 logistic 回归分析 B1 和 B2 之间骨质疏松症剂量依赖性增加的比值比 (or)。采用受试者工作特征 (ROC) 曲线下面积分析 UBCR 预测骨质疏松的能力。结果骨质疏松组 UBCR 明显增高。调整多个混杂因素后，UBCR 水平与腰椎 BMD 及 T 和 Z 值呈负相关。B2 UBCR 组腰椎 BMD 及 T 和 Z 值明显低于 B1 UBCR 组。与 B1 参与者相比，在调整了潜在的混杂因素后，通过二元 logistic 回归分析，B2 参与者 “骨质疏松” 的 or 值高 12.401 倍 (P = 0.005)。UBCR 指数 (cutoffi = 362.48 μ g/g) 鉴别骨质疏松症的敏感性为 78.6%，特异性为 68.7%，ROC 曲线下面积为 0.760。结论 UBCR 水平与腰椎 BMD 及 T 、 Z 值呈负相关，可作为中国老年男性骨质疏松的标志。
METHODS::Apparent calcium absorption, total bone mineral content and density, and mineral contents of the right femur were studied using a growing rat model. Twenty-four male Wistar rats were fed with diets based on extruded whole grain red (RSD) or white sorghum (WSD), and control diet (CD) up to 60 days. The animals fed with sorghum diets consumed less and gained less weight compared to those fed with CD, but the efficiency of all diets was similar. Calcium intake was lower in animals fed with sorghum diets, related to the lower total intake of these animals. Apparent calcium absorption in animals fed with RSD was lower than in those fed with CD (CD: 72.7%, RSD: 51.0%, WSD: 64.8%). No significant differences in bone mineral density of total body, spin, femur, distal femur, tibia and proximal tibia were observed among the groups. However, Ca and P contents in the right femur of the rats consuming RSD were lower, indicating a certain imbalance in the metabolism of these minerals.
METHODS:OBJECTIVE:Controversy exists about the impact of bone mineral density (BMD) and fracture risk in newly diagnosed patients with breast cancer (BC). It is presumed that there are differences in BMD between women with BC and healthy controls. BMD is therefore considered as a potential marker to predict BC risk. This study was conducted to investigate the association of BMD, trabecular bone score (TBS) and fracture risk in younger postmenopausal women with hormone responsive BC. METHODS:Overall, 343 women were examined. Women with BC were matched to a control group of the general population. Forty-nine women and fifty-nine controls were included in the final analysis. All subjects underwent dual energy x-ray absorptiometry (DXA) of the lumbar spine, femoral neck, and the total hip to evaluate bone mineral density. The 10-year fracture risk for a major osteoporotic fracture was assessed using the FRAX-score and the TBS-adjusted FRAX-Score, respectively. RESULTS:Lumbar and femoral neck BMD were similar in BC patients and controls. No difference was found for TBS of the spine (1.38 ± 0.1 vs.1.36 ± 0.09) in the BC and the control group, respectively (p = 0.19). The 10- year probability for a major osteoporotic fracture (MoF) or femoral neck (FN) fracture was 6.1 (± 2.6%) and 0.9 (± 1.2%) in the BC group vs. 6.7 (± 3.5%) (p = 0.33) and 0.9 (± 1.1%) (p = 0.73) in the control group. CONCLUSION:Postmenopausal women younger than 60 years with breast cancer do not show any differences in baseline BMD, TBS, or TBS adjusted FRAX in comparison to controls.
METHODS::The goals of this study are to evaluate the ability of the multicomponent collagen-elastin-like polypeptide (ELP)-Bioglass scaffolds to support osteogenesis of rat mesenchymal stem cells (rMSCs), demonstrate in vivo biocompatibility by subcutaneous implantation in Sprague-Dawley rats, monitor degradation noninvasively, and finally assess the scaffold's ability in healing critical-sized cranial bone defects. The collagen-ELP-Bioglass scaffold supports the in vitro osteogenic differentiation of rMSCs over a 3 week culture period. The cellular (rMSC-containing) or acellular scaffolds implanted in the subcutaneous pockets of rats do not cause any local or systemic toxic effects or tumors. The real-time monitoring of the fluorescently labeled scaffolds by IVIS reveals that the scaffolds remain at the site of implantation for up to three weeks, during which they degrade gradually. Micro-CT analysis shows that the bilateral cranial critical-sized defects created in rats lead to greater bone regeneration when filled with cellular scaffolds. Bone mineral density and bone microarchitectural parameters are comparable among different scaffold groups, but the histological analysis reveals increased formation of high-quality mature bone in the cellular group, while the acellular group has immature bone and organized connective tissue. These results suggest that the rMSC-seeded collagen-ELP-Bioglass composite scaffolds can aid in better bone healing process.