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High Body Mass Index and Central Adiposity Is Associated with Increased Risk of Acute Pancreatitis: A Meta-Analysis

高体重指数和中心性肥胖与急性胰腺炎风险增加相关: 一项荟萃分析

  • 影响因子:2.46
  • DOI:10.1007/s10620-020-06275-6
  • 作者列表:"Aune, Dagfinn","Mahamat-Saleh, Yahya","Norat, Teresa","Riboli, Elio
  • 发表时间:2020-06-19
Abstract

Background Higher body mass index and waist circumference have been associated with increased risk of pancreatitis in several prospective studies; however, the results have not been entirely consistent. Aims We conducted a systematic review and dose-response meta-analysis of prospective studies on adiposity and risk of pancreatitis to clarify this association. Methods PubMed and Embase databases were searched for studies on adiposity and pancreatitis up to January 27, 2020. Prospective studies reporting adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) for the association between adiposity and risk of pancreatitis were included, and summary RRs (95% CIs) were calculated using a random effects model. Results Ten prospective studies with 5129 cases and 1,693,657 participants were included. The summary RR (95% CI) of acute pancreatitis was 1.18 (95% CI: 1.03–1.35, I ^2 = 91%, n  = 10 studies) per 5 kg/m^2 increase in BMI and 1.36 (95% CI: 1.29–1.43, I ^2 = 0%, n  = 3) per 10 cm increase in waist circumference. There was evidence of a nonlinear association between BMI and acute pancreatitis, p _nonlinearity < 0.0001, with a steeper association at higher levels of BMI, but not for waist circumference, p _nonlinearity = 0.19. Comparing a BMI of 35 with a BMI of 22, there was a 58% increase in the RR and there was a fourfold increase in the RR comparing a waist circumference of 110 cm with 69 cm. There was no evidence of publication bias. Conclusions This meta-analysis suggests that both increasing BMI and waist circumference are associated with a dose-response-related increase in the risk of acute pancreatitis.

摘要

背景在一些前瞻性研究中,较高的体重指数和腰围与胰腺炎风险增加相关; 然而,结果并不完全一致。我们对肥胖和胰腺炎风险的前瞻性研究进行了系统综述和剂量-反应荟萃分析,以阐明这一相关性。方法检索PubMed和Embase数据库中截至 2020 年 1 月 27 日有关肥胖和胰腺炎的研究。纳入报告肥胖与胰腺炎风险相关性的校正相对风险 (RR) 估计值和 95% 置信区间 (ci) 的前瞻性研究,并总结RRs (95% ci) 使用随机效应模型计算。结果共纳入 10 项前瞻性研究,5129 例病例,1,693,657 例参与者。急性胰腺炎的汇总RR (95% CI) 为 1.18 (95% CI: 1.03-1.35,I ^ 2 = 91%,n = 10 项研究) BMI每增加 5千克/m ^ 2,腰围每增加 1.36,增加 95% (1.29 CI: 1.43-0%,I ^ 2 = 10厘米,n = 3)。有证据表明BMI和急性胰腺炎之间存在非线性关联,p _ 非线性 <0.0001,在较高水平的BMI时关联更陡峭,但腰围无关,p _ 非线性 = 0.19。BMI为 35 与BMI为 22 相比,RR增加了 58%,RR增加了 4 倍,腰围为 110厘米与 69厘米相比。没有发表偏倚的证据。结论这项荟萃分析表明,BMI和腰围的增加都与急性胰腺炎风险的剂量反应相关增加有关。

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