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18F-NaF-PET/CT in patients with primary hyperparathyroidism and brown tumors.

原发性甲状旁腺功能亢进和棕色肿瘤患者的 18F-NaF-PET/CT。

  • 影响因子:2.29
  • DOI:10.1007/s00774-019-01059-z
  • 作者列表:"Graf C","Huellner M","Tschopp O","Bode-Lesniewska B","Schmid C
  • 发表时间:2020-05-01
Abstract

INTRODUCTION:Brown tumors (BT) are non-neoplastic bone lesions infrequently occurring in patients with long-standing severe hyperparathyroidism (HPT). BT may be identified and characterized using 18-F-sodium fluoride-positron-emission-tomography/computed tomography (18F-NaF-PET/CT). We present a retrospective series of eight primary hyperparathyroidism (pHPT) patients with BT imaged with 18F-NaF-PET/CT. MATERIALS AND METHODS:Imaging assessment included location, diameter, maximum standardized uptake value (SUVmax), metabolically active lesion volume (PETvol) of BT, total metabolically active bone volume (TMBvol) per patient and several computed tomography (CT) features of BT. Where appropriate, we analyzed the association between characteristic features of BT in 18F-NaF-PET/CT, histopathology, clinical symptomatology and laboratory parameters. RESULTS:In our cohort of 8 patients (median age, 49 years, range, 26-73), 72 BT were found. The mean PETvol of BT was 89.48 cm3 ± 122.81 cm3 and the mean SUVmax was 17.5 ± 7.8. The total PETvol of BT per patient correlated positively with serum calcium (r = 0.810, p = 0.015), and negatively with glomerular filtration rate (GFR) (r = - 0.762, p = 0.028). TMBvol correlated significantly with serum PTH (r = 0.810, p = 0.015), alkaline phosphatase (r = 0.762, p = 0.028), and duration of postoperative hospitalization (r = 0.826, p = 0.011, 24.3 days ± 19.8 days). CONCLUSION:18F-NaF-PET/CT is a valuable non-invasive whole-body imaging technique for the assessment of patients with pHPT and BT. TMBvol is associated with PTH and alkaline phosphatase, and the requirement for intense postoperative calcium substitution, which determines the duration of hospitalization.

摘要

简介: 棕色肿瘤 (BT) 是一种非肿瘤性骨病变,在长期严重甲状旁腺功能亢进 (HPT) 患者中不常见。BT可使用 18-F-氟化钠-正电子发射断层扫描/计算机断层扫描 (18F-NaF-PET/CT) 进行鉴定和表征。我们对 8 例原发性甲状旁腺功能亢进症 (pHPT) 患者进行了 18F-NaF-PET/CT成像的BT回顾性系列研究。 材料和方法: 影像学评估包括位置、直径、最大标准化摄取值 (SUVmax) 、BT的代谢活跃病变体积 (PETvol) 、总代谢活跃骨体积 (TMBvol) 每个患者和BT的几个计算机断层扫描 (CT) 特征。在适当的情况下,我们分析了 18F-NaF-PET/CT中BT的特征、组织病理学、临床症状学和实验室参数之间的关联。 结果: 在我们的 8 例患者队列 (中位年龄,49 岁,范围,26-73) 中,发现 72 BT。BT的平均PETvol为 89.48立方厘米 ± 122.81立方厘米,平均SUVmax为 17.5 ± 7.8。每个患者BT的总PETvol与血清钙呈正相关 (r = 0.810,p = 0.015),与肾小球滤过率 (GFR) 呈负相关 (R =  -  0.762,p = 0.028)。TMBvol与血清PTH (r = 0.810,p = 0.015) 、碱性磷酸酶 (r = 0.762,p = 0.028) 显著相关,和术后住院时间 (r = 0.826,p = 0.011,24.3 天 ± 19.8 天)。 结论: 18F-NaF-PET/CT是评估pHPT和BT患者的一种有价值的无创全身成像技术。TMBvol与PTH和碱性磷酸酶以及术后强烈钙替代的需求相关,这决定了住院时间。

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DOI:10.1177/1078155219842277
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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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