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Effect of granulocyte colony-stimulating factor on bone marrow: evaluation by intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging.

粒细胞集落刺激因子对骨髓的影响: 通过体素内不相干运动和动态对比增强磁共振成像评价。

  • 影响因子:1.82
  • DOI:10.1007/s11547-019-01115-8
  • 作者列表:"Minutoli F","Pergolizzi S","Blandino A","Mormina E","Amato E","Gaeta M
  • 发表时间:2020-03-01
Abstract

OBJECTIVE:To report our experience with the use of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI in bone marrow before and after administration of granulocyte colony-stimulating factor (GCSF). Moreover, a small series of patients with bone metastases from breast cancer have been evaluated by IVIM DW-MRI and DCE-MRI before and after GCSF administration. MATERIALS AND METHODS:We studied with IVIM-MRI and DCE-MRI 14 patients with rectal or uterine cervix cancer studied before and 4-18 days after administration of GCSF; the second MR examination was obtained after three chemotherapy courses. IVIM perfusion fraction (f), pseudo-diffusion coefficient (D*), true diffusion coefficient (D) and apparent diffusion coefficient (ADC) as well area under the curve at 60 s (AUC60) were calculated for bone marrow before and after GCSF administration. Moreover, two different IVIM parametric maps (i.e., ADC and ADClow) were generated by selecting two different intervals of b values (0-1000 and 0-80, respectively). Furthermore, four patients affected by pelvic bone metastases from breast adenocarcinoma who received GCSF administration were also qualitatively evaluated for evidence of lesions on ADC maps, ADClow maps and DCE-MRI. RESULTS:ADC, D, D*, f and AUC60 values were significantly higher in hyperplastic bone marrow than in untreated bone marrow (p values < 0.0001, < 0.0001, < 0.001, < 0.001, < 0.0001, respectively). All bone metastases were clearly differentiable from hyperplastic bone marrow on ADClow maps, but not on ADC maps and DCE-MRI. CONCLUSION:MR functional imaging techniques, such as DW-, IVIM DW- and DCE-MRI are effective tools in assessing the response of bone marrow to the administration of growth factors. Although an overlap between signal of hyperplastic bone marrow and lytic bone metastases can occur on ADC maps and DCE-MRI, evaluation of ADClow maps by IVIM DW-MRI could permit to differentiate hyperplastic bone marrow from lytic bone metastases. Further studies are needed to confirm our data.

摘要

目的: 报告体素内不相干运动 (IVIM) 磁共振成像 (MRI) 和动态对比增强 (DCE) 的使用经验。-粒细胞集落刺激因子 (GCSF) 给药前后骨髓MRI。此外,在GCSF给药前后,对一小部分乳腺癌骨转移患者进行了IVIM DW-MRI和DCE-MRI评估。 材料和方法: 对 14 例直肠癌或宫颈癌患者应用GCSF治疗前和治疗后 4 ~ 18 天进行IVIM-MRI和DCE-MRI检查; 第二次MR检查是在三个化疗疗程后获得的。IVIM灌注分数 (f) 、伪扩散系数 (D *) 、真扩散系数 (D) 和表观扩散系数 (ADC) 同时计算GCSF给药前后骨髓 60 s曲线下面积 (AUC60)。此外,两个不同的IVIM参数映射 (ADC和adclaw) 通过选择两个不同间隔的b值 (分别为 0-1000 和 0-80) 产生。此外,还对 4 例接受GCSF给药的乳腺腺癌骨盆骨转移患者进行了ADC图、ADClow图和DCE-MRI上病变证据的定性评估。 结果: 增生骨髓的ADC、D * 、f和AUC60 值明显高于未处理骨髓 (p值 <0.0001,<0.0001,<0.001,<0.001,<0.0001)。所有骨转移灶在ADClow图上均可与增生的骨髓清楚区分,但在ADC图和DCE-MRI上无明显区别。 结论: MR功能成像技术,如DW-、IVIM DW-和DCE-MRI是评估骨髓对生长因子治疗反应的有效工具。虽然在ADC图和DCE-MRI上可以出现增生骨髓和溶骨性骨转移信号之间的重叠,通过IVIM DW-MRI评价ADClow图谱可以区分增生的骨髓和溶解的骨转移。需要进一步的研究来证实我们的数据。

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

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影响因子:2.83
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