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Surgical treatment of metastatic mesenchymal chondrosarcoma to the spine: A case report.

手术治疗脊柱转移性间叶性软骨肉瘤 1 例。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000018643
  • 作者列表:"Liu S","Zhou X","Song A","Huo Z","Wang Y","Liu Y
  • 发表时间:2020-01-01
Abstract

INTRODUCTION:Metastatic mesenchymal chondrosarcoma of the spine is a highly unusual disease without standard curative managements yet. The objective of this case report is to present a very rare case of metastatic chondrosarcoma to the spine successfully operated by surgical treatment. The management of these unique cases has yet to be well-documented. PATIENT CONCERNS:A 34-year-old woman presented with a 4-month history of continuous and progressive back pain and a 1-month history of radiating pain of bilateral lower extremities. The patient, who had been diagnosed of mesenchymal chondrosarcoma of maxillary sinus for 3 years, received surgical treatment of palliative endoscopic-assisted total left maxillary resection via mini Caldwell-Luc approach, and palliative enlarged resection due to the progress of residual lesions, followed by no adjuvant therapy. Multiple lytic, expanding lesions of the spine and paraspinal region with severe epidural spinal cord compression was identified. DIAGNOSIS:CT, MRI and bone scan of spine showed spinal cord compression secondary to the epidural component of the metastatic lesions. Post-operative pathology confirmed the diagnosis of metastatic spinal mesenchymal chondrosarcomas. INTERVENTIONS:The patient underwent posterior spinal canal decompression, resection of T12 and L3 lesions, internal fixation of T11-L5 pedicles, and cement augmentation of T12 and L3. OUTCOMES:The patient's neurological deficits improved significantly after the surgery, and the postoperative period was uneventful at the 1-year follow-up visit. There were no complications associated with the spinal surgery during the follow-up period. CONCLUSION:Metastatic spinal mesenchymal chondrosarcoma, although rare, should be part of the differential diagnosis when the patient presents with back pain and radiculopathy. We recommend the posterior approach for spinal decompression and total resection of the metastatic chondrosarcoma when the tumor has caused neurological deficits or other severe symptoms. Osteoplasty by cement augmentation is also a good choice for surgical treatment in some patients.

摘要

引言: 脊柱转移性间叶性软骨肉瘤是一种非常罕见的疾病,目前尚无标准的治疗方法。本病例报告的目的是介绍一例通过手术治疗成功的脊柱转移性软骨肉瘤的非常罕见的病例。这些独特案例的管理尚未得到很好的记录。 患者顾虑: 女性,34 岁,有 4 个月的持续、进行性背痛病史,1 个月的双侧下肢放射痛病史。患者,已确诊上颌窦间叶性软骨肉瘤 3 年,接受内镜辅助下经mini Caldwell-Luc入路姑息性左上颌骨全切手术治疗,而姑息性扩大切除术由于残留病灶的进展,随后无辅助治疗。发现脊柱和椎旁区多发性溶解、扩大的病变伴严重硬膜外脊髓压迫。 诊断: 脊柱CT、MRI和骨扫描显示转移性病灶硬膜外成分继发脊髓压迫。术后病理证实为转移性脊柱间叶性软骨肉瘤。 干预措施: 患者行后路椎管减压,切除T12 、L3 病变,T11-L5 椎弓根内固定,骨水泥强化T12 、L3。 结果: 患者术后神经功能缺损明显改善,术后 1 年随访期间顺利。随访期间无脊柱手术相关并发症。 结论: 转移性脊髓间叶性软骨肉瘤虽然罕见,但当患者出现背痛和神经根病时,应作为鉴别诊断疾病的一部分。当肿瘤引起神经功能缺损或其他严重症状时,我们推荐后路脊柱减压和全切除转移性软骨肉瘤。骨水泥隆骨术也是部分患者手术治疗的良好选择。

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

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影响因子:2.83
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DOI:10.1007/s00520-019-04843-9
作者列表:["Dohzono S","Sasaoka R","Takamatsu K","Hoshino M","Nakamura H"]

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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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