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SMARCB1-Deficient Sinonasal Carcinoma: Systematic Review and Case Report.

鼻腔鼻窦肿瘤SMARCB1-Deficient系统评价及病例报告

  • 影响因子:1.52
  • DOI:10.1016/j.wneu.2020.01.130
  • 作者列表:"Parsel SM","Jawad BA","McCoul ED
  • 发表时间:2020-04-01
Abstract

INTRODUCTION:To describe the current state of literature involving SMARCB1/INI-1 deficient sinonasal carcinoma (SDSC) and examine a case at our institution. METHODS:A systematic search was performed using the Population, Intervention, Comparator, Outcome, and Study Design approach. Search criteria included all occurrences in the title or abstract of the terms: "integrase interactor 1 deficient," "INI1 deficient," or "SMARCB1 deficient" and "sinonasal carcinoma." The main outcomes were disease-free survival, all-cause mortality, rates of recurrence, or metastases. RESULTS:Systematic search yielded 13 studies for final review. All studies were either case series or case reports with 82 cases of SDSC published since 2014. Age on presentation ranged from 19 to 75 years, with the majority of patients being male. Surgical resection was the primary modality of treatment with adjuvant radiation or chemoradiation therapy. Overall, the prognosis was poor, with most tumors presenting at advanced stages with an overall median (range) survival of 22 (12-44) months with an average (standard deviation) of 45.3% (33.1%) of patients dying of the disease. An average (standard deviation) of 38.2% (34.0%) of patients had no evidence of disease at follow-up. Studies comparing sinonasal undifferentiated carcinoma to SDSC reported worse prognosis for SDSC and increased risk for locoregional recurrence in the latter cohort. CONCLUSIONS:SDSC represents a highly aggressive tumor presenting at advanced stage with propensity of metastasis. More research is necessary to determine the optimal treatment modality and management.

摘要

介绍: 描述涉及SMARCB1/INI-1 缺陷型鼻腔鼻窦癌 (SDSC) 的文献现状,并检查我们机构的 1 例病例。 方法: 采用人群、干预、对照、结局和研究设计方法进行系统检索。检索标准包括术语 “整合酶interactor 1 缺陷” 、 “INI1 缺陷” 或 “SMARCB1 缺陷” 和 “鼻腔鼻窦癌” 的标题或摘要中的所有出现。主要结局为无病生存率、全因死亡率、复发率或转移率。 结果: 系统检索获得 13 项研究进行最终审查。所有研究均为病例系列或病例报告,自 2014 年以来发表了 82 例SDSC。就诊年龄 19 ~ 75 岁,患者多为男性。手术切除是辅助放疗或放化疗治疗的主要方式。总体而言,预后较差,大多数肿瘤表现为晚期,总体中位 (范围) 生存期为 22 (12-44) 个月,平均 (标准差) 45.3% (33.1%) 的患者死于该病。平均 (标准差) 38.2% (34.0%) 的患者在随访时没有疾病证据。比较鼻腔鼻窦未分化癌与SDSC的研究报告了SDSC的预后更差,后者的局部区域复发风险增加。 结论: SDSC代表一种高度侵袭性肿瘤,表现为晚期转移倾向。需要更多的研究来确定最佳的治疗方式和管理。

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

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影响因子:2.83
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DOI:10.1007/s00520-019-04843-9
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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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