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Manual and semiautomatic segmentation of bone sarcomas on MRI have high similarity.

MRI上手动和半自动分割骨肉瘤具有很高的相似性。

  • 影响因子:1.82
  • DOI:10.1590/1414-431X20198962
  • 作者列表:"Dionísio FCF","Oliveira LS","Hernandes MA","Engel EE","Rangayyan RM","Azevedo-Marques PM","Nogueira-Barbosa MH
  • 发表时间:2020-01-31
Abstract

:The aims of this study were to evaluate the intra- and interobserver reproducibility of manual segmentation of bone sarcomas in magnetic resonance imaging (MRI) studies and to compare manual and semiautomatic segmentation methods. This retrospective study included twelve osteosarcoma and eight Ewing sarcoma MRI studies performed prior to any therapeutic intervention. All cases were histopathologically confirmed. Three radiologists used 3D-Slicer software to perform manual segmentation of bone sarcomas in a blinded and independent manner. One radiologist segmented manually and also performed semiautomatic segmentation with the GrowCut tool. Segmentation exercises were timed for comparison. The dice similarity coefficient (DSC) and Hausdorff distance (HD) were used to evaluate similarity between the segmentation results and further statistical analyses were performed to compare DSC, HD, and volumetric results. Manual segmentation was reproducible with intraobserver DSC varying from 0.83 to 0.97 and HD from 3.37 to 28.73 mm. Interobserver DSC of manual segmentation showed variation from 0.73 to 0.97 and HD from 3.93 to 33.40 mm. Semiautomatic segmentation compared to manual segmentation resulted in DSCs of 0.71-0.96 and HDs of 5.38-31.54 mm. Semiautomatic segmentation required significantly less time compared to manual segmentation (P value ≤0.05). Among all situations compared, tumor volumetry did not show significant statistical differences (P value >0.05). We found excellent intra- and interobserver agreement for manual segmentation of osteosarcoma and Ewing sarcoma. There was high similarity between manual and semiautomatic segmentation, with a significant reduction of segmentation time using the semiautomatic method.

摘要

: 本研究的目的是评估磁共振成像 (MRI) 研究中手动分割骨肉瘤的观察者内和观察者间再现性,并比较手动和半自动分割方法。这项回顾性研究包括在任何治疗干预之前进行的 12 项骨肉瘤和 8 项尤文肉瘤MRI研究。所有病例均经病理证实。3 名放射科医生使用 3D-Slicer软件,以盲法独立的方式对骨肉瘤进行手动分割。一位放射科医生手动分割,并用GrowCut工具进行半自动分割。分段练习定时进行比较。使用dice相似系数 (DSC) 和Hausdorff距离 (HD) 评价分割结果之间的相似性,并进行进一步的统计分析,比较DSC、HD和体积结果。手动分割可重复,intraobserver DSC从 0.83 到 0.97,HD从 3.37 到 28.73毫米。Interobserver DSC的手动分割显示从 0.73 到 0.97 的变化,HD从3.93 到 33.40毫米。与手动分割相比,半自动分割导致DSCs为 0.71-0.96,HDs为 5.38-31.54毫米。与手动分割相比,半自动分割需要的时间明显更少 (p值≤ 0.05)。在所有情况比较中,肿瘤体积测定未显示显著统计学差异 (p值> 0.05)。我们发现手动分割骨肉瘤和尤文肉瘤的观察者内和观察者间一致性极好。手动分割和半自动分割之间具有很高的相似性,使用半自动方法的分割时间显著减少。

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DOI:10.1177/1078155219842277
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影响因子:2.83
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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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