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Long non-coding RNA small nucleolar RNA host gene 7 expression level in prostate cancer tissues predicts the prognosis of patients with prostate cancer.

长非编码RNA小核仁RNA宿主基因 7 在前列腺癌组织中的表达水平预测前列腺癌患者的预后。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000018993
  • 作者列表:"Xia Q","Li J","Yang Z","Zhang D","Tian J","Gu B
  • 发表时间:2020-02-01
Abstract

:Long non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) is located on chromosome 9q34.3 in length of 984 bp. SNHG7 has been found to play the role of oncogene in varieties of cancers, and its dysregulation has been found to be associated with carcinogenesis and progression. In the present study, we examined the expression of SNHG7 in prostate cancer tissues and in paired adjacent normal prostate tissues, and we further explored the clinical significance and prognostic value of SNHG7 in prostate cancer patients.A total of 127 prostate cancer tissues were collected from prostate cancer patients who underwent radical prostatectomy between April 2011 and March 2019 at the department of urology, Pudong New Area People's Hospital. Real-time quantitative polymerase chain reaction experiment was performed to detect the relative expressions of SNHG7 in the prostate cancer tissues and normal prostate tissues. The Kaplan-Meier method was used to create survival curves and the log-rank test was used to determine statistical significance. A Cox proportional hazard analysis was used to evaluate the prognostic factors in univariate and multivariate analyses.Compared with paired adjacent normal prostatic tissues, SNHG7 expression was increased in prostate cancer tissues (P < .001). Increased SNHG7 expression correlated with Gleason score (P = .021), bone metastasis (P = .013), pelvic lymph node metastasis (P = .008), and TNM stage (P = .007). Multivariate Cox regression analyses revealed increased SNHG7 expression was independently associated with a poor prognosis of prostate cancer patients (hazard ratio [HR] = 2.839, 95% confidence interval [CI] = 1.921-8.382, P = .038).This study showed that lncRNA-SNHG7 was overexpressed in prostate cancer tissues, and it might contributes to the development and progression of prostate cancer. Furthermore, the SNHG7 expression was associated with the prognosis of prostate cancer, suggesting a potential target for the treatment and prognosis of prostate cancer. Nevertheless, the underlying modulatory mechanism by which SNHG7 aggravates prostate cancer progression need to be further studied.

摘要

: 长非编码小核仁RNA宿主基因 7 (lncRNA SNHG7) 位于染色体 9q34.3 上,长度为 984  bp。SNHG7 被发现在多种癌症中发挥癌基因的作用,其失调被发现与癌症的发生和发展相关。在本研究中,我们检测了SNHG7 在前列腺癌组织和配对癌旁正常前列腺组织中的表达,我们进一步探讨了SNHG7 在前列腺癌患者中的临床意义和预后价值。收集 2011 年 4 月至 2019 年 3 月在浦东新区人民医院泌尿外科接受根治性前列腺切除术的前列腺癌患者的前列腺癌组织,共 127 例。采用实时定量聚合酶链反应法检测SNHG7 在前列腺癌组织和正常前列腺组织中的相对表达。Kaplan-Meier法绘制生存曲线,log-rank检验确定统计学显著性。在单变量和多变量分析中,采用Cox比例风险分析评估预后因素。与癌旁正常前列腺组织相比,前列腺癌组织中SNHG7 表达增加 (p <.001)。SNHG7 表达增加与Gleason评分 (p =.021) 、骨转移 (p =.013) 、盆腔淋巴结转移 (p =.008) 相关,TNM分期 (p =.007)。多因素Cox回归分析显示,SNHG7 表达增加与前列腺癌患者的不良预后独立相关 (风险比 [HR] = 2.839,95% 置信区间 [CI] = 1.921-8.382,p =.038)。本研究表明lncRNA-SNHG7 在前列腺癌组织中过表达,可能参与了前列腺癌的发生、发展。此外,SNHG7 表达与前列腺癌的预后相关,提示前列腺癌治疗和预后的潜在靶点。尽管如此,SNHG7 加重前列腺癌进展的潜在调节机制仍有待进一步研究。

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