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Metastatic castration-resistant prostate cancer: Academic insights and perspectives through bibliometric analysis.

转移性去势抵抗性前列腺癌: 通过文献计量分析的学术见解和观点。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000019760
  • 作者列表:"He L","Fang H","Chen C","Wu Y","Wang Y","Ge H","Wang L","Wan Y","He H
  • 发表时间:2020-04-01
Abstract

BACKGROUND:In recent years, metastatic castration-resistant prostate cancer (MCRPC) and studies related to MCRPC have drawn global attention. The main objective of this bibliometric study was to provide an overview of MCRPC, explore clusters and trends in research and investigate the future direction of MCRPC research. METHODS:A total of 4089 publications published between 1979 and 2018 were retrieved from the Web of Science (WoS) Core Collection database. Different aspects of MCRPC research, including the countries/territories, institutions, journals, authors, research areas, funding agencies and author keywords, were analyzed. RESULTS:The number of annual MCRPC publications increased rapidly after 2010. American researchers played a vital role in this increase, as they published the most publications. The most productive institution was Memorial Sloan Kettering Cancer Center. De Bono, JS (the United Kingdom [UK]) and Scher, HI (the United States of America [USA]) were the two most productive authors. The National Institutes of Health (NIH) funded the largest number of published papers. Analyses of keywords suggested that therapies (abiraterone, enzalutamide, etc.) would attract global attention after US Food and Drug Administration (FDA) approval. CONCLUSIONS:Developed countries, especially the USA, were the leading nations for MCRPC research because of their abundant funding and frequent international collaborations. Therapy was one of the most vital aspects of MCRPC research. Therapies targeting DNA repair or the androgen receptor (AR) signing pathway and new therapies especially prostate-specific membrane antigen (PSMA)-based radioligand therapy (RLT) would be the next focus of MCRPC research.

摘要

背景: 近年来,转移性去势抵抗性前列腺癌 (MCRPC) 及其相关研究已引起全球关注。本文献计量研究的主要目的是提供MCRPC的概述,探索研究的集群和趋势,并调查MCRPC研究的未来方向。 方法: 从Web of Science (WoS) 核心收藏数据库中检索到 1979 年至 4089 年间发表的共 2018 篇出版物。分析了MCRPC研究的不同方面,包括国家/地区、机构、期刊、作者、研究领域、资助机构和作者关键词。 结果: 2010 年后MCRPC年度出版物数量快速增长。美国研究人员在这一增长中发挥了至关重要的作用,因为他们发表的出版物最多。最有成效的机构是纪念斯隆凯特林癌症中心。De Bono,JS (英国 [UK]) 和Scher,HI (美利坚合众国 [USA]) 是两位最有生产力的作者。美国国立卫生研究院 (NIH) 资助的论文数量最多。对关键词的分析表明,在美国食品和药物管理局 (FDA) 批准后,治疗 (阿比特龙、enzalutamide等) 将引起全球关注。 结论: 发达国家,特别是美国,由于资金雄厚,国际合作频繁,是MCRPC研究的主要国家。治疗是MCRPC研究中最重要的方面之一。靶向DNA修复或雄激素受体 (AR) 签署通路的疗法和新疗法,特别是基于前列腺特异性膜抗原 (PSMA) 的放射配体治疗 (RLT) 将是MCRPC研究的下一个重点。

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DOI:10.1259/bjr.20180883
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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

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影响因子:2.83
发表时间:2020-01-01
DOI:10.1007/s00520-019-04843-9
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骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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