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Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women.

IV期子宫内膜癌远处转移部位的预后价值: 2948 例女性的SEER数据库研究。

  • 影响因子:1.80
  • DOI:10.1002/ijgo.13084
  • 作者列表:"Liu Y","Chi S","Zhou X","Zhao R","Xiao C","Wang H
  • 发表时间:2020-04-01
Abstract

OBJECTIVE:To evaluate the prognosis of women with distant metastasis at the time of endometrial cancer (EC) diagnosis and identify prognostic factors according to metastatic site. METHODS:A retrospective cohort study of women diagnosed with EC according to the SEER database between 2010 and 2014. Univariate and multivariate Cox regression was used to identify variables associated with overall survival. Kaplan-Meier curves were used to compare survival among different groups. RESULTS:Overall, 2948 women with stage IV EC were identified. The most common distant metastatic site was the lung. Having a distant metastatic site independently predicted overall survival. Using brain metastasis as a reference, overall survival was longer for liver (P=0.049), lung (P=0.005), and bone (P=0.019) metastasis. Relative to no distant metastasis, overall survival was shorter for women with one (P<0.001) or two or more (P<0.001) sites of distant metastasis. Overall survival was independently influenced by tumor grade, insurance status, and surgery among women with only lung metastasis. CONCLUSION:The findings showed that the prognosis of women with stage IV EC differs by distant metastatic site, and identified several predictors of poor survival. They may help clinicians to better predict prognosis for newly diagnosed cases of EC with distant metastasis.

摘要

目的: 评估子宫内膜癌 (EC) 诊断时远处转移妇女的预后,并根据转移部位确定预后因素。 方法: 根据SEER数据库 2010 年至 2014 年间诊断为EC的女性的回顾性队列研究。使用单变量和多变量Cox回归来确定与总生存期相关的变量。Kaplan-Meier曲线用于比较不同组间的生存率。 结果: 总体上,确定了 2948 例IV期EC女性患者。最常见的远处转移部位是肺。具有远处转移部位可独立预测总生存期。以脑转移为参考,肝 (P = 0.049) 、肺 (P = 0.005) 和骨 (P = 0.019) 转移的总生存期更长。相对于无远处转移,有一个 (P<0.001) 或两个或更多 (P<0.001) 远处转移部位的女性的总生存期较短。在仅有肺转移的女性中,肿瘤分级、保险状态和手术独立影响总生存期。 结论: 研究结果表明,IV期EC女性的预后因远处转移部位而异,并确定了生存不良的几个预测因素。它们可能有助于临床医生更好地预测新诊断的EC远处转移病例的预后。

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发表时间:2020-03-01
DOI:10.1259/bjr.20180883
作者列表:["Tran S","Puric E","Walser M","Poel R","Datta NR","Heuberger J","Pica A","Marder D","Lomax N","Bolsi A","Morach P","Bachtiary B","Seddon BM","Schneider R","Bodis S","Weber DC"]

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

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影响因子:2.83
发表时间:2020-01-01
DOI:10.1007/s00520-019-04843-9
作者列表:["Dohzono S","Sasaoka R","Takamatsu K","Hoshino M","Nakamura H"]

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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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