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Long-term Survival After Surgical Treatment of Spinal Metastasis - The Predictive Role of Sex.

脊柱转移手术治疗后的长期生存 -- 性别的预测作用。

  • 影响因子:1.90
  • DOI:10.21873/anticanres.14091
  • 作者列表:"Karimi D","Morgen SS","Fruergaard S","Gehrchen M","Dahl B
  • 发表时间:2020-03-01
Abstract

BACKGROUND/AIM:An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. PATIENTS AND METHODS:A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was investigated. The follow-up period was 10 years. RESULTS:Survival time was significantly longer for women compared to men (mean±SD: 29±5.2 vs. 14±3.6 month (p=0.01). With adjusted analysis, this difference remained statistically significant. After adjusting for specific primary tumor type and time since surgery, the hazard-ratio of 10-year survival for men compared to women was 1.47 (95% confidence intervaI=1.01-2.18, p=0.048). CONCLUSION:These findings indicate that sex is associated with long-term survival in patients treated for MSCC.

摘要

背景/目的: 越来越多的患者接受手术治疗转移性脊髓压迫 (MSCC)。然而,性别作为长期生存的独立预测因子的可能作用尚未研究。本研究旨在探讨性别是否与MSCC患者手术治疗后的长期生存相关。 患者和方法: 从 2005 年到 2006 年,共有 110 例患者接受了MSCC手术。研究了性别与总生存期之间的关系。随访时间为 10 年。 结果: 与男性相比,女性的生存时间显著更长 (平均值 ± SD: 29 ± 5.2 vs. 14 ± 3.6 个月 (p = 0.01)。通过调整分析,这种差异仍然具有统计学意义。在调整了特定的原发肿瘤类型和自手术以来的时间后,男性与女性相比的 10 年生存率的风险比为 1.47 (95% 置信区间intervaI = 1.01-2.18,p = 0.048)。 结论: 这些研究结果表明,性别与MSCC治疗患者的长期生存相关。

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发表时间:2020-03-01
DOI:10.1259/bjr.20180883
作者列表:["Tran S","Puric E","Walser M","Poel R","Datta NR","Heuberger J","Pica A","Marder D","Lomax N","Bolsi A","Morach P","Bachtiary B","Seddon BM","Schneider R","Bodis S","Weber DC"]

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

翻译标题与摘要 下载文献
影响因子:2.83
发表时间:2020-01-01
DOI:10.1007/s00520-019-04843-9
作者列表:["Dohzono S","Sasaoka R","Takamatsu K","Hoshino M","Nakamura H"]

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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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