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Nasal adenocarcinoma associated with jaagsiekte sheep retrovirus infection in a sheep.

与jaagsiekte绵羊逆转录病毒感染相关的鼻腺癌。

  • 影响因子:1.24
  • DOI:10.1177/1040638719897032
  • 作者列表:"Jahns H","Cousens C
  • 发表时间:2020-01-01
Abstract

:Betaretrovirus-induced transmissible respiratory tumors in sheep arise at 2 distinct anatomic locations, either deep in the lung tissue caused by jaagsiekte sheep retrovirus (JSRV) or in the nasal cavity induced by ovine enzootic nasal tumor virus (ENTV-1). JSRV and ENTV-1 are found in many countries worldwide and have a significant economic and animal health impact. Although JSRV is endemic in sheep in the British Isles, ENTV-1 has not been reported. We report herein a nasal adenocarcinoma in a cull 8-y-old Belclare ewe from Ireland. The gross and microscopic features and immunohistochemistry results were consistent with an ENTV-1-associated tumor. However, differential PCR, using primers specific to regions of divergent sequence between the viruses, was performed on different parts of the adenocarcinoma and produced consistent results: positive for JSRV and negative for ENTV-1. An association of JSRV with nasal adenocarcinoma in sheep has not been reported previously, to our knowledge. Our case shows the necessity of using PCR in combination with immunohistochemistry to reach an accurate etiologic diagnosis, which is of importance in countries currently free of ENTV-1.

摘要

: Β 受体病毒诱导的绵羊传染性呼吸道肿瘤发生在两个不同的解剖部位,要么发生在jaagsiekte绵羊受体病毒 (JSRV) 引起的肺组织深处或在鼻腔内诱发羊流行性鼻肿瘤病毒 (ENTV-1)。JSRV和ENTV-1 存在于世界许多国家,对经济和动物健康有重大影响。虽然JSRV在英伦三岛的绵羊中流行,但ENTV-1 尚未见报道。我们在此报道了来自爱尔兰的一只 8 岁的Belclare母羊的一个鼻腺癌。大体和镜下特征及免疫组化结果均符合肿瘤ENTV-1-associated。然而,使用病毒之间分歧序列区域的特异性引物,对腺癌的不同部位进行差异PCR,并产生一致的结果: JSRV阳性,ENTV-1 阴性。据我们所知,JSRV与绵羊鼻腺癌的相关性尚未见报道。我们的病例显示了使用PCR结合免疫组织化学来达到准确的病因学诊断的必要性,这在目前没有ENTV-1 的国家是重要的。

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DOI:10.1259/bjr.20180883
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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

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影响因子:2.83
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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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