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Oncologic outcomes after surgery for locally aggressive basal cell carcinoma of the head and neck.
局部侵袭性头颈部基底细胞癌术后的肿瘤学结局。
- 影响因子:2.32
- DOI:10.1002/lary.27882
- 作者列表:"Gill AS","Nittur VR","Moore MG","Farwell DG","Bewley AF
- 发表时间:2020-01-01
Abstract
OBJECTIVE:Although basal cell carcinoma (BCC) is the most common skin cancer, locally aggressive BCC of the head and neck is rare and not well studied. STUDY DESIGN:Retrospective review of patients who underwent primary surgical resection of locally aggressive head and neck BCC at a single tertiary academic center. RESULTS:Eighty-seven patients with 98 tumors demonstrated a 5-year Kaplan-Meier estimated recurrence-free survival of 64.5%, overall survival of 83.3%, and disease-specific survival of 98.3%. Intraoperative positive frozen section margin was a strong independent predictor of local recurrence (hazard ratio 6.88, P = 0.038) and was more likely to occur in tumors previously treated with radiation (odds ratio 6.47 = 0.05). CONCLUSION:Locally aggressive BCCs of the head and neck have high rates of local recurrence but low disease-specific mortality when treated with primary surgery and selected use of adjuvant therapy. Intraoperative positive frozen section margin is a strong independent predictor of local recurrence and is more likely in tumors that were previously treated with radiation therapy. LEVEL OF EVIDENCE:4 Laryngoscope, 130:115-119, 2020.
摘要
目的: 虽然基底细胞癌 (BCC) 是最常见的皮肤癌,但头颈部局部侵袭性BCC罕见,研究尚不充分。 研究设计: 回顾性审查在单个三级学术中心接受局部侵袭性头颈部BCC一期手术切除的患者。 结果: 87 例 98 个肿瘤患者的 5 年Kaplan-Meier估计无复发生存率为 64.5%,总生存率为 83.3%,疾病特异性生存率为 98.3%。术中冰冻切缘阳性是局部复发的强独立预测因子 (风险比 6.88,P = 0.038) 且更可能发生在既往接受放射治疗的肿瘤中 (比值比 6.47 = 0.05)。 结论: 头颈部局部侵袭性BCCs在初次手术和选择辅助治疗时局部复发率高,但疾病特异性死亡率低。术中冰冻切缘阳性是局部复发的强独立预测因子,在既往接受过放射治疗的肿瘤中更有可能。 证据级别: 4 喉镜,130:115-119,2020。
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皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。