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Cutaneous Leiomyosarcoma: A SEER Database Analysis.

皮肤平滑肌肉瘤: SEER数据库分析。

  • 影响因子:1.25
  • DOI:10.1097/DSS.0000000000002029
  • 作者列表:"Sandhu N","Sauvageau AP","Groman A","Bogner PN
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Cutaneous leiomyosarcoma is a rare dermal neoplasm usually arising from the pilar smooth muscle. It is considered a relatively indolent neoplasm, and there is debate whether designation as sarcoma is appropriate. Owing to some conflicting data in the literature, however, its behavior warrants further clarification. OBJECTIVE:To determine the clinical behavior and demographic and pathologic characteristics of cutaneous leiomyosarcoma. MATERIALS AND METHODS:The Surveillance, Epidemiology and End Results database was used to collect data on cutaneous leiomyosarcoma and 2 reference populations: cutaneous angiosarcoma (aggressive) and atypical fibroxanthoma (indolent). Demographic and oncologic characteristics were examined, and overall survivals (OS) and disease-specific survivals were compared. RESULTS:Leiomyosarcoma and atypical fibroxanthoma displayed lower stage (localized: 69.7% and 66.8% respectively), smaller size (<3 cm: 90.5% and 72%), and lower rates of disease-specific mortality (2.9% and 7.8%) compared with angiosarcoma. Patients with leiomyosarcoma had a 5-year disease-specific survival rate of 98% and OS rate of 85%. CONCLUSION:Cutaneous leiomyosarcoma shows outcomes similar to atypical fibroxanthoma. It is nearly always indolent and should be distinguished from more aggressive cutaneous and subcutaneous sarcomas. Clear communication of the biologic potential may be best achieved using alternate diagnostic terminology such as "atypical intradermal smooth-muscle neoplasm."

摘要

背景: 皮肤平滑肌肉瘤是一种罕见的皮肤肿瘤,通常起源于皮平滑肌。它被认为是一种相对惰性的肿瘤,命名为肉瘤是否合适存在争议。然而,由于文献中的一些相互矛盾的数据,其行为值得进一步澄清。 目的: 探讨皮肤平滑肌肉瘤的临床表现、人口学和病理学特征。 材料和方法: 利用监测流行病学学和最终结果数据库收集皮肤平滑肌肉瘤和 2 个参考人群的数据: 皮肤血管肉瘤 (侵袭性) 和非典型纤维黄色瘤 (惰性)。检查人口统计学和肿瘤学特征,并比较总体生存率 (OS) 和疾病特异性生存率。 结果: 平滑肌肉瘤和非典型纤维黄色瘤表现为较低的分期 (分别为 69.7% 和 66.8%),较小的尺寸 (<3 cm: 90.5% 和 72%),与血管肉瘤相比,疾病特异性死亡率较低 (2.9% 和 7.8%)。平滑肌肉瘤患者的 5 年疾病特异性生存率为 98%,OS率为 8 5%。 结论: 皮肤平滑肌肉瘤的结果与非典型纤维黄色瘤相似。它几乎总是惰性的,应该与更具侵袭性的皮肤和皮下肉瘤区分开来。使用替代诊断术语如 “非典型皮内平滑肌肿瘤” 可以最好地实现生物学潜能的明确交流。

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影响因子:2.93
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METHODS:BACKGROUND:Human papillomavirus (HPV) infections are associated with common dermatologic and nondermatologic diseases. Although HPV vaccines are well established as preventive measures for genital warts and cervical neoplasia, their use as therapeutic agents deserves greater attention. OBJECTIVE:To evaluate the use of HPV vaccine(s) as a treatment modality for cutaneous and/or mucosal disease. METHODS:A primary literature search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted in January 2019 by using the PubMed and Cochrane databases. RESULTS:A total of 63 articles with 4439 patients were included. The majority of patients with cutaneous warts, recurrent respiratory papillomatosis, and squamous and basal cell carcinomas were successfully treated with HPV vaccination. Preliminary data on patients with pre-existing anogenital warts, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, and vulvar intraepithelial neoplasia is promising. LIMITATIONS:This review was limited by the lack of controls, patients' previous HPV vaccination status, and publication bias. CONCLUSION:The commercially available three-dose, quadrivalent HPV vaccine is a potential therapeutic option for the treatment of cutaneous warts, recurrent respiratory papillomatosis, and squamous and basal cell carcinomas. Noncommercially available HPV vaccines demonstrate therapeutic response for treating anogenital warts, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, and vulvar intraepithelial neoplasia. The vaccine's efficacy as an adjunct therapy for HPV-associated cutaneous and/or mucosal disease warrants further exploration.

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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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