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STAT3, STAT5A, STAT5B and STAT6 proteins are overexpressed in human basal cell carcinoma.

STAT3 、STAT5A、STAT5B和STAT6 蛋白在人基底细胞癌中过表达。

  • 影响因子:1.09
  • DOI:10.1111/ced.14048
  • 作者列表:"Sławińska M","Lakomy J","Biernat W","Sokołowska-Wojdyło M","Karczewska J","Zabłotna M","Jankau J","Nowicki RJ","Sobjanek M
  • 发表时间:2020-03-01
Abstract

BACKGROUND:The molecular pathogenesis of basal cell carcinoma (BCC) is still not precisely described and is the subject of ongoing studies. The role of signal transducers and activators of transcription (STATs) in human epithelial carcinogenesis has been poorly investigated, but in the era of studies on inhibitors targeting STAT proteins this topic seems worth exploring. Increased expression of STAT3 in human nonmelanoma skin cancer (NMSC) has been confirmed in a few studies, but to our knowledge, expression of STAT5A, STAT5B and STAT6 in BCC has not been previously evaluated. AIM:To measure expression of STAT3, STAT5A, STAT5B and STAT6 expression in different histopathological subtypes of human BCC and its correlation with selected clinical variables. METHODS:Immunohistochemistry was used to assess 60 BCC tumour specimens [20 superficial (s)BCCs, 20 nodular (n)BCCs and 20 infiltrative (i)BCCs] and to compare with specimens of healthy skin. There was no significant difference in age or sex between the three groups of patients with BCC. As many tumours showed heterogeneity of staining, the H-score system was applied to calculate the intensity of immunoexpression. RESULTS:Expression of STAT3, STAT5A, STAT5B and STAT6 was observed in all histopathological subtypes of BCC, and was stronger than the expression within the adjacent epidermis and also stronger than the expression within the epidermis in the healthy control group. Statistical analysis revealed no significant differences in mean H-scores calculated for sBCCs, nBCCs and iBCCs. There were no statistically significant associations between STAT3, STAT5A, STAT5B and STAT6 expression and patient sex/age, and tumour size/site. CONCLUSION:Our results confirm a possible role of STATs in the pathogenesis of BCC and should encourage future investigations on the possible therapeutic implications of this finding.

摘要

背景: 基底细胞癌 (BCC) 的分子发病机制仍没有精确描述,是正在进行的研究的主题。信号转导子和转录激活子 (STATs) 在人类上皮癌变中的作用研究甚少,但在针对STAT蛋白的抑制剂研究时代,这一课题似乎值得探索。STAT3 在人非黑色素瘤皮肤癌 (NMSC) 中的表达增加已在一些研究中得到证实,但据我们所知,STAT5A、STAT5B和STAT6 在BCC中的表达尚未被评估。 目的: 检测STAT3 、STAT5A、STAT5B和STAT6 在不同组织病理学亚型BCC中的表达及其与临床变量的相关性。 方法S: immunhi s tochemi s try wa s u s ed to a s s e s 60 BCC tumor s pecimen s [20 s uperficial (s)BCC s,20 个结节性 (n)BCC s和 20 个浸润性 (i)BCC s],并与健康s亲属的s pecimen s进行比较。3 组BCC患者的年纪或性别差别无统计学意义。由于许多肿瘤显示染色异质性,应用H评分系统计算免疫表达强度。 结果: STAT3 、STAT5A、STAT5B和STAT6 在BCC各组织病理学亚型中均有表达,并且在健康对照组中强于相邻表皮内的表达,也强于表皮内的表达。统计分析显示,计算的sBCCs、nBCCs和iBCCs的平均H评分无显著差异。STAT3 、STAT5A、STAT5B和STAT6 表达与患者性别/年龄、肿瘤大小/部位之间无统计学显著相关性。 结论: 我们的结果证实了STATs在BCC发病机制中的可能作用,并应鼓励今后研究这一发现可能的治疗意义。

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影响因子:2.93
发表时间:2020-01-01
DOI:10.1016/j.jaad.2019.04.067
作者列表:["Pham CT","Juhasz M","Sung CT","Mesinkovska NA"]

METHODS:BACKGROUND:Human papillomavirus (HPV) infections are associated with common dermatologic and nondermatologic diseases. Although HPV vaccines are well established as preventive measures for genital warts and cervical neoplasia, their use as therapeutic agents deserves greater attention. OBJECTIVE:To evaluate the use of HPV vaccine(s) as a treatment modality for cutaneous and/or mucosal disease. METHODS:A primary literature search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted in January 2019 by using the PubMed and Cochrane databases. RESULTS:A total of 63 articles with 4439 patients were included. The majority of patients with cutaneous warts, recurrent respiratory papillomatosis, and squamous and basal cell carcinomas were successfully treated with HPV vaccination. Preliminary data on patients with pre-existing anogenital warts, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, and vulvar intraepithelial neoplasia is promising. LIMITATIONS:This review was limited by the lack of controls, patients' previous HPV vaccination status, and publication bias. CONCLUSION:The commercially available three-dose, quadrivalent HPV vaccine is a potential therapeutic option for the treatment of cutaneous warts, recurrent respiratory papillomatosis, and squamous and basal cell carcinomas. Noncommercially available HPV vaccines demonstrate therapeutic response for treating anogenital warts, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, and vulvar intraepithelial neoplasia. The vaccine's efficacy as an adjunct therapy for HPV-associated cutaneous and/or mucosal disease warrants further exploration.

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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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