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C-C chemokine receptor 4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders, and its implications for diagnosis and treatment.

C-C c hemokine重新c ep t或 4 表达C D8 + c u t aneous T-c ell淋巴瘤和lymphoprolifera t我紊乱,并且i t s impli c a t离子用于诊断和t rea t men t。

  • 影响因子:2.67
  • DOI:10.1111/his.13960
  • 作者列表:"Geller S","Hollmann TJ","Horwitz SM","Myskowski PL","Pulitzer M
  • 发表时间:2020-01-01
Abstract

AIMS:Patients with aggressive CD8+ cutaneous T-cell lymphomas (CTCLs) progress rapidly and respond poorly to therapy. Confounding treatment planning, there is clinicopathological overlap between aggressive CD8+ CTCLs and other lymphoproliferative disorders (LPDs). Hence, improved diagnostic methods and therapeutic options are needed. The aim of this study was to examine C-C chemokine receptor 4 (CCR4) expression as a diagnostic and therapeutic biomarker in CD8+ CTCLs/LPDs. METHODS AND RESULTS:Forty-nine cases (41 patients) with CD8+ CTCLs/LPDs were examined, including CD8+ mycosis fungoides (MF) (n = 14), aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (AETCL) (n = 8), subcutaneous panniculitis-like T-cell lymphoma (SPTCL) (n = 7), CD30+ LPDs (n = 6), primary cutaneous γδ T-cell lymphoma (GDTCL) (n = 6), and others (n = 8). Immunohistochemical tissue staining was performed with a CCR4 monoclonal antibody on formalin-fixed paraffin-embedded tissue sections. CCR4 immunostaining was graded as percentage infiltrate, i.e. high (>25%) and low (≤25%), and the results were correlated with clinicopathological diagnoses. CCR4 expression was seen in 69% of the studied cases. Any CCR4 positivity was seen in all CD8+ MF cases, in 83% of CD30+ LPD cases, in 75% of AETCL cases, in 33% of GDTCL cases, and in none of the SPTCL cases. High CCR4 expression was seen in 79% of CD8+ MF cases versus 33% of CD30+ LPD cases, in 17% of GDTCL cases, and in 12.5% of AETCL cases. Patients with more advanced MF stage had higher CCR4 expression. CONCLUSIONS:CCR4 immunohistochemistry may be an adjunct in distinguishing advanced CD8+ MF from other CD8+ CTCLs/LPDs. Although CCR4 expression may justify therapeutic targeting of this receptor in CD8+ MF, the role of such therapies in other CD8+ CTCLs/LPDs is not yet clear.

摘要

目的: Pa t ien t s wi t h积极CD8 + cu t aneous T细胞淋巴瘤 (C T CLs) 进展迅速反应不佳t o t herapy.混杂治疗计划,侵袭性CD8 + CTCLs与其他淋巴增殖性疾病 (LPDs) 之间存在临床病理重叠。因此,需要改进诊断方法和治疗选择。本研究的目的是检查C-C的c血红素c受体 4 (C C R 4) 表达作为diagnosti c和治疗ti c生物标志物在C D8 + C T C Ls/LPDs中。 ME T HODS和RESUL T S: 对t y-9 例 (41 pa t ien t s) wi t h CD8 + C T CLs/LPDs进行检查,包括CD8 + 蕈样肉芽肿 (MF) (n = 14) 、侵袭性表皮t (ropic) CD8 + cy t o t oxic T细胞淋巴瘤 (AE T CL) (n = 8) 、subcu t panniculi t是样T细胞淋巴瘤 (SP T CL) (n = 7),CD30 + LPDs (n = 6),原发性cu t同期 γ δ T细胞淋巴瘤 (GD T CL) (n = 6),o t hers (n = 8)。用CCR4 单克隆抗体在福尔马林固定石蜡包埋的组织切片上进行免疫组织化学染色。CCR4 免疫染色分级为百分比浸润,即高 (>25%) 和低 (≤ 25%),结果与临床病理诊断相关。69% 的研究病例可见CCR4 表达。在所有CD8 + MF病例中,在 83% 的CD30 + LPD病例中,在 75% 的AETCL病例中,在 33% 的GDTCL病例中,在没有SPTCL病例中观察到任何CCR4 阳性。高CCR4 表达见于 79% 的CD8 + MF病例与 33% 的CD30 + LPD病例、 17% 的GDTCL病例和 12.5% 的AETCL病例。MF分期越晚期的患者CCR4 表达越高。 结论: CCR4 免疫组化可能是区分晚期CD8 + MF和其他CD8 + CTCLs/LPDs的辅助手段。虽然CCR4 的表达可能证明该受体在CD8 + MF中的治疗靶向是合理的,但这种治疗在其他CD8 + CTCLs/LPDs中的作用尚不清楚。

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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