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Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome.

低剂量全皮肤电子束治疗: 蕈样肉芽肿或Sezary综合征患者维持和辅助治疗的生活质量改善和临床影响。

  • 影响因子:1.93
  • DOI:10.1007/s00066-019-01517-7
  • 作者列表:"Elsayad K","Kroeger K","Greve B","Moustakis C","Assaf C","Stadler R","Lenz G","Weishaupt C","Eich HT
  • 发表时间:2020-01-01
Abstract

PURPOSE:Total skin electron beam therapy (TSEBT) has proved to be a safe and effective treatment for cutaneous T‑cell lymphomas. Here, we examined the impact of this treatment on patient quality of life and outcome. PATIENTS AND METHODS:Forty-four patients with mycosis fungoides (MF) or Sezary syndrome (SS) received 48 TSEBT courses with a median dose of 12 Gy within the past 8 years at our institute. Patient and treatment characteristics for these cases as well as the impact of TSEBT on quality of life and duration of response were retrospectively analyzed and compared. RESULTS:The median modified Severity-Weighted Assessment Tool score before the start of TSEBT was 44. The overall response rate was 88%, with a complete response (CR) rate of 33%. The median follow-up period was 13 months. The median duration of response (DOR) and progression-free survival (PFS) for the entire cohort were 10 months and 9 months, respectively. Patient-reported symptom burden was measured with the Dermatological Life Quality Index and Skindex-29 questionnaires. The mean symptom reductions were 6 ± 8 (P = 0.005) and 21 ± 24 (P = 0.002), respectively. In the Functional Assessment of Cancer Therapy-General Assessment, significant improvements in the emotional (P = 0.03) domains were observed after TSEBT. Patients who received maintenance or adjuvant treatments had a longer PFS (P = 0.01). CONCLUSION:TSEBT improved disease symptoms and significantly improved emotional domains of patients' quality of life in patients with MF or SS. In addition, our results indicate that maintenance or adjuvant therapy after TSEBT may improve the PFS.

摘要

目的: 全皮肤电子束治疗 (TSEBT) 已被证明是皮肤t细胞淋巴瘤的一种安全有效的治疗方法。在此,我们研究了这种治疗对患者生活质量和结局的影响。 患者和方法: 在过去 8 年内,44 例蕈样肉芽肿 (MF) 或Sezary综合征 (SS) 患者接受了 48 个TSEBT疗程,中位剂量为 12 gy。回顾性分析和比较这些病例的患者和治疗特征以及TSEBT对生活质量和反应持续时间的影响。 结果: TSEBT开始前改良严重程度加权评估工具评分的中位数为 44。总体应答率为 88%,完全应答 (CR) 率为 33%。中位随访时间为 13 个月。整个队列的中位缓解时间 (DOR) 和无进展生存期 (PFS) 分别为 10 个月和 9 个月。患者报告的症状负担采用皮肤病生活质量指数和Skindex-29 问卷进行测量。平均症状减轻分别为 6 ± 8 (p = 0.005) 和 21 ± 24 (p = 0.002)。在癌症治疗的功能评估-一般评估中,TSEBT后观察到情绪 (p = 0.03) 领域的显著改善。接受维持治疗或辅助治疗的患者PFS较长 (p = 0.01)。 结论: TSEBT改善了MF或SS患者的疾病症状,显著改善了患者生活质量的情绪领域。此外,我们的结果表明,TSEBT后的维持或辅助治疗可能改善PFS。

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影响因子:0.96
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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