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Thrombotic Hemangioma With Organizing/Anastomosing Features: Expanding the Spectrum of GNA-mutated Hemangiomas With a Predilection for the Skin of the Lower Abdominal Regions.

具有组织/吻合特征的血栓性血管瘤: 扩大GNA突变的血管瘤谱,好发于下腹部皮肤。

  • 影响因子:6.06
  • DOI:10.1097/PAS.0000000000001392
  • 作者列表:"Liau JY","Lee JC","Tsai JH","Chen CC","Wang YH","Chung YC
  • 发表时间:2020-02-01
Abstract

:In this study, we aimed to present the clinicopathologic and molecular features of a distinct group of hemangioma with GNA mutations that exhibited prominent thrombosis and organization changes with florid intravascular endothelial cell proliferation that we provisionally termed "thrombotic hemangioma with organizing/anastomosing features." Twenty-six cases were included. No sex predilection was seen (male:female=13:13). Patients' age ranged from 17 to 89 years (median: 51 y). All but 1 occurred in the skin whereas the remaining tumor involved the neck soft tissue. Remarkably, the majority (18) occurred in the lower abdominal/inguinal regions. Histologically, thrombotic hemangioma with organizing/anastomosing features were circumscribed tumors composed of variably sized and congested thin-walled vessels. The most striking features were prominent thrombosis and organization with florid intravascular endothelial cell proliferation. The proliferating endothelial cells exhibit a streaming pattern with focal anastomosing-like feature resembling anastomosing hemangioma. The stroma was sclerotic or hyalinized but could also be myxoid/edematous. Other features included vessels with nuclear hobnailing and perivascular hyalinization, cherry hemangioma-like component, cavernous-like or sinusoidal hemangioma-like areas, Masson hemangioma-like feature, and spindle cell fascicular pattern. Mitotic activity was usually low and nuclei were bland but 2 tumors exhibited moderate nuclear atypia and higher mitotic activity. Extramedullary hematopoiesis and hyaline globules were not identified. Genetically, by Sanger sequencing and MassARRAY analysis, mutually exclusive GNAQ, GNA11, and GNA14 exon 5 mutations were identified in 15, 5, and 2 tumors, respectively, with a combined mutation rate of 85% (22/26). In conclusion, we described a distinct group of hemangioma and expanded the clinicopathologic features of GNA-mutated hemangiomas.

摘要

: 在这项研究中,我们的目的是介绍一组具有GNA突变的血管瘤的临床病理和分子特征,这些血管瘤表现出突出的血栓形成和组织变化,伴随着丰富的血管内内皮细胞增殖,我们暂时称之为 “有组织的血栓性血管瘤”。/吻合特征。"纳入 26 例病例。未见性别倾向 (男性: 女性 = 13:13)。患者年龄 17 ~ 89 岁 (中位数: 51 岁)。除 1 例外均发生于皮肤,其余肿瘤累及颈部软组织。值得注意的是,大多数 (18) 发生在下腹部/腹股沟区。组织学上,具有组织/吻合特征的血栓性血管瘤是由大小不等、充血的薄壁血管组成的局限性肿瘤。最显著的特征是突出的血栓形成和组织伴有丰富的血管内内皮细胞增殖。增殖的内皮细胞表现出类似于吻合血管瘤的局灶性吻合样特征的流动模式。间质硬化或透明,但也可以是粘液样/水肿。其他特征包括血管有核片钉和血管周围玻璃样变,樱桃状血管瘤样成分,海绵状或窦状血管瘤样区,Masson血管瘤样特征,梭形细胞束状模式。核分裂活性通常较低,细胞核平淡,但 2 例肿瘤表现出中等的核异型性和较高的核分裂活性。未发现髓外造血和透明球。遗传学上,通过Sanger测序和MassARRAY分析,分别在 15 、 5 和 2 个肿瘤中发现了相互排斥的GNAQ、GNA11 和GNA14 外显子 5 突变,合并突变率为 85% (22/26)。总之,我们描述了一组不同的血管瘤,并扩展了GNA突变血管瘤的临床病理特征。

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影响因子:2.93
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DOI:10.1016/j.jaad.2019.04.067
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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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