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Early-stage Mycosis Fungoides: Epidemiology and Prognosis.

早期蕈样肉芽肿流行病学和预后。

  • 影响因子:2.00
  • DOI:10.2340/00015555-3367
  • 作者列表:"Maguire A","Puelles J","Raboisson P","Chavda R","Gabriel S","Thornton S
  • 发表时间:2020-01-07
Abstract

:Most patients with mycosis fungoides are diagnosed with early-stage disease. However, prevalence of early-stage disease is unknown, and evidence of its burden is scarce. The aim of this study is to estimate the prevalence of early-stage mycosis fungoides, how long patients live with early-stage disease and to characterise these patients. Data were obtained from 4 key publications and from US cancer registries (Surveillance, Epidemiology and End Results Program; SEER). The derived incidence of early-stage mycosis fungoides was 0.26/100,000 (UK), 0.29/100,000 (US) and 0.38/100,000 (US-SEER) and the prevalence was 4.8/100,000 (UK), 5.2/100,000 (US) and 6.6/100,000 (US-SEER). Early-stage disease may last for 18 years. From SEER registries, 3,132 were diagnosed at early stage (mostly stage IA). Median age at diagnosis was 58 years. Compared with stage IA, the relative risk of death was 1.3 for stage IB and 3.5 for stage IIA. We confirm the rarity of early-stage mycosis fungoides, a differential prognosis and the potential for elevated burden of disease.

摘要

: 大多数蕈样肉芽肿患者被诊断为早期疾病。然而,早期疾病的患病率尚不清楚,其负担的证据也很少。本研究的目的是估计早期蕈样肉芽肿的患病率,早期疾病患者的生存时间以及这些患者的特征。数据来自 4 个关键出版物和美国癌症登记处 (监测流行病学学和最终结果项目; SEER)。早期蕈样肉芽肿的衍生发病率为 0.26/100,000 (英国) 、 0.29/100,000 (美国) 和 0.38/100,000 (美国-SEER) 患病率分别为 4.8/100,000 (英国) 、 5.2/100,000 (美国) 和 6.6/100,000 (美国-SEER)。早期疾病可能持续 18 年。来自SEER登记处,3,132 的患者在早期诊断 (大部分为IA期)。诊断时的中位年龄为 58 岁。与IA期相比,IB期的相对死亡风险为 1.3,IIA期的相对死亡风险为 3.5。我们证实了早期蕈样肉芽肿的罕见性、不同的预后和疾病负担升高的可能性。

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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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