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Premenopausal Use of Progestogens and Cutaneous Melanoma Risk: A French Prospective Cohort Study.

绝经前使用孕激素与皮肤黑色素瘤风险: 一项法国前瞻性队列研究。

  • 影响因子:3.32
  • DOI:10.1093/aje/kwz240
  • 作者列表:"Cervenka I","Al Rahmoun M","Mahamat-Saleh Y","Boutron-Ruault MC","Fournier A","Kvaskoff M
  • 发表时间:2020-04-02
Abstract

:We investigated the influence of premenopausal use of progestogens on melanoma using data from E3N (Etude Epidémiologique Auprès de Femmes de l'Education Nationale), a prospective cohort of 98,995 French women, aged 40-65 years at inclusion. We used Cox models to adjust for age and melanoma risk factors. Over 1992-2008, 540 melanoma cases were ascertained among 79,558 women. We found a modest association between self-reported progestogen use and melanoma risk (hazard ratio (HR) = 1.23, 95% confidence interval (CI) = 1.02, 1.47), which was reduced after adjustment for melanoma risk factors (HR = 1.15, 95% CI: 0.95, 1.39). There was no heterogeneity across types of progestogens (P = 0.22), and use of multiple progestogens was positively associated with melanoma risk (HR = 1.33, 95% CI: 1.04, 1.70). Among users, we found no relationship with duration of progestogen use, age at start and last use, and time since first and last use. Although our results did not show evidence of a confounding effect of sun exposure, progestogen users had lower levels of residential sun exposure and were more likely to report sunscreen use, suggesting specific sun exposure profiles in users. Our findings do not support a strong influence of progestogens on melanoma risk. Further research is needed to confirm these results.

摘要

: 我们使用来自E3N (Etude epid é miologique aupr è s de Femmes de l 'education Nationale) 的数据,研究了绝经前使用孕激素对黑色素瘤的影响,E3N是一个由 98,995 名法国女性组成的前瞻性队列,纳入时年龄 40-65 岁。我们使用Cox模型调整年龄和黑色素瘤风险因素。超过 1992-2008,在 540 名妇女中确定了 79,558 例黑色素瘤病例。我们发现自我报告的孕激素使用与黑色素瘤风险之间存在适度关联 (风险比 (HR) = 1.23,95% 置信区间 (CI) = 1.02,1.47),在校正黑色素瘤危险因素后,这一比例降低 (HR = 1.15,95% CI: 0.95,1.39)。孕激素类型之间没有异质性 (P = 0.22),使用多种孕激素与黑色素瘤风险呈正相关 (HR = 1.33,95% CI: 1.04,1.70)。在使用者中,我们没有发现与孕激素使用持续时间、开始和最后一次使用时的年龄以及自第一次和最后一次使用以来的时间有关。尽管我们的结果没有显示阳光暴露的混杂效应的证据,孕激素使用者的住宅阳光暴露水平较低,更有可能报告防晒霜的使用,建议用户特定的阳光暴露配置文件。我们的研究结果不支持孕激素对黑色素瘤风险的强烈影响。需要进一步的研究来证实这些结果。

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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