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Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma.

皮肤T细胞淋巴瘤患者皮损中抗菌肽表达失调。

  • 影响因子:2.00
  • DOI:10.2340/00015555-3372
  • 作者列表:"Wehkamp U","Jost M","Wehkamp K","Harder J
  • 发表时间:2020-01-07
Abstract

:Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to in inflammatory skin conditions. Samples from 20 patients with cutaneous T-cell lymphoma were analysed using immunohistochemistry and enzyme-linked immunoassay (ELISA) of skin washing fluids of hBD-2, hBD-3, RNase 7 and psoriasin. Immunohistochemistry results were compared with previous analyses of healthy and psoriatic skin. ELISA and immunohistochemistry revealed a higher expression of psoriasin in lesional cutaneous T-cell lymphoma compared with non-lesional and healthy samples. Immunohistochemistry showed an increase in hBD-2 in lesional cutaneous T-cell lymphoma skin compared with healthy skin. The expression profile of antimicrobial peptides in cutaneous T-cell lymphoma appears to be dysregulated, indicating a potential role of antimicrobial peptides in cutaneous T-cell lymphoma. A larger prospective study and functional studies are needed to improve our understanding of the role of antimicrobial peptides in cutaneous T-cell lymphoma.

摘要

: 蕈样肉芽肿和s é zary综合征属于原发性皮肤T细胞淋巴瘤。由于皮损的炎症表现,我们假设抗菌肽在这些条件下可能失调,类似于炎症性皮肤条件。对 20 例皮肤T细胞淋巴瘤患者的皮肤冲洗液进行免疫组织化学和酶联免疫分析 (ELISA),检测hBD-2 、hBD-3 、RNase 7 和银屑病皮损。将免疫组织化学结果与以前对健康和银屑病皮肤的分析进行比较。ELISA和免疫组化显示银屑病在皮损型皮肤T细胞淋巴瘤中的表达高于非皮损型和健康对照。免疫组化显示与健康皮肤相比,皮损皮肤T细胞淋巴瘤皮肤的hBD-2 增加。皮肤T细胞淋巴瘤中抗菌肽的表达谱似乎失调,表明抗菌肽在皮肤T细胞淋巴瘤中的潜在作用。需要更大的前瞻性研究和功能研究来提高我们对抗菌肽在皮肤T细胞淋巴瘤中的作用的理解。

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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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