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The clinico-pathological spectrum of primary cutaneous lymphoma other than mycosis fungoides/Sezary syndrome.

蕈样肉芽肿/Sezary综合征以外的原发性皮肤淋巴瘤的临床病理谱。

  • 影响因子:2.52
  • DOI:10.1007/s00428-019-02713-7
  • 作者列表:"Oschlies I","King RL","Dotlic S","Montes-Moreno S","Ponzoni M","Traverse-Glehen A","Calaminici M","Ferry JA","Ott G","Goodlad JR
  • 发表时间:2020-05-01
Abstract

:The major aim of Session 1 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop was to collect examples of cutaneous lymphomas, excluding mycosis fungoides/Sezary syndrome, as defined in the current WHO classification of tumours of the haemetopoietic and lymphoid tissues. Overall 42 cases were submitted. These were considered in four main categories: primary cutaneous B cell lymphomas (12 cases), primary cutaneous T cell lymphomas/lymphoproliferations with CD8+/cytotoxic phenotype (12 cases), primary cutaneous CD30-positive lymphoproliferative disorders (15 cases) and primary cutaneous T cell lymphomas/leukaemias with CD4+ phenotype (4 cases). Using these cases as examples, we were able to present the full spectrum of cutaneous lymphoproliferations (excluding mycosis fungoides/Sezary syndrome), including examples of rare, provisional and new entities as listed in the 2017 update of the WHO classification. The findings are summarized in this report with emphasis on differential diagnostic considerations and the importance of clinico-pathological correlation for final subtyping. In presenting these findings we hope to raise awareness of this enigmatic group of neoplasms and to further our understanding of these rare disease entities.

摘要

: 2018 欧洲血液病理学协会/血液病理学会研讨会第一场会议的主要目的是收集皮肤淋巴瘤的例子,不包括蕈样肉芽肿/Sezary综合征,根据目前WHO造血和淋巴组织肿瘤分类中的定义。总共提交了 42 起案件。这些被认为是四个主要类别: 原发性皮肤b细胞淋巴瘤 (12 例),原发性皮肤T细胞淋巴瘤/淋巴细胞增殖伴CD8 +/细胞毒性表型 (12 例),原发性皮肤CD30-positive淋巴组织增生性疾病 (15 例) 和CD4 + 表型的原发性皮肤T细胞淋巴瘤/白血病 (4 例)。以这些病例为例,我们能够呈现皮肤淋巴增生的全谱 (不包括蕈样肉芽肿/Sezary综合征),包括罕见的例子,世卫组织分类 2017 更新中列出的临时实体和新实体。本报告总结了这些发现,重点是鉴别诊断考虑和临床-病理相关性对最终亚分型的重要性。在介绍这些发现时,我们希望提高对这组神秘肿瘤的认识,并进一步了解这些罕见疾病实体。

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影响因子:0.96
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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