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The neutrophil-lymphocyte ratio and locoregional melanoma: a multicentre cohort study.

中性粒细胞-淋巴细胞比率与局部黑素瘤: 一项多中心队列研究。

  • 影响因子:4.40
  • DOI:10.1007/s00262-019-02478-7
  • 作者列表:"Robinson AV","Keeble C","Lo MCI","Thornton O","Peach H","Moncrieff MDS","Dewar DJ","Wade RG
  • 发表时间:2020-04-01
Abstract

OBJECTIVES:The neutrophil-lymphocyte ratio (NLR) is an inflammatory biomarker which is useful in cancer prognostication. We aimed to investigate the differences in baseline NLR between patients with localised and metastatic cutaneous melanoma and how this biomarker changed over time with the recurrence of disease. METHODS:This multicentre cohort study describes patients treated for Stage I-III cutaneous melanoma over 10 years. The baseline NLR was measured immediately prior to surgery and again at the time of discharge or disease recurrence. The odds ratios (OR) for sentinel node involvement are estimated using mixed-effects logistic regression. The risk of recurrence is estimated using multivariable Cox regression. RESULTS:Overall 1489 individuals were included. The mean baseline NLR was higher in patients with palpable nodal disease compared to those with microscopic nodal or localised disease (2.8 versus 2.4 and 2.3, respectively; p < 0.001). A baseline NLR ≥ 2.3 was associated with 30% higher odds of microscopic metastatic melanoma in the sentinel lymph node [adjusted OR 1.3 (95% CI 1.3, 1.3)]. Following surgery, 253 patients (18.7%) developed recurrent melanoma during surveillance although there was no statistically significant association between the baseline NLR and the risk of recurrence [adjusted HR 0.9 (0.7, 1.1)]. CONCLUSION:The NLR is associated with the volume of melanoma at presentation and may predict occult sentinel lymph metastases. Further prospective work is required to investigate how NLR may be modelled against other clinicopathological variables to predict outcomes and to understand the temporal changes in NLR following surgery for melanoma.

摘要

目的: 中性粒细胞-淋巴细胞比率 (NLR) 是一种炎性生物标志物,可用于癌症预后。我们旨在研究局限性和转移性皮肤黑色素瘤患者之间基线NLR的差异,以及随着疾病复发,该生物标志物如何随时间变化。 方法: 这项多中心队列研究描述了 10 年间接受I-III期皮肤黑色素瘤治疗的患者。术前立即测量基线NLR,出院或疾病复发时再次测量。使用混合效应logistic回归估计前哨淋巴结受累的比值比 (OR)。使用多变量Cox回归估计复发风险。 结果: 共纳入 1489 例个体。触诊淋巴结疾病患者的平均基线NLR高于显微镜下淋巴结或局部疾病患者 (分别为 2.8 vs 2.4 和 2.3; P <0.001)。基线nlr ≥ 2.3 与前哨淋巴结微小转移性黑色素瘤的发生率高 30% 相关 [校正OR 1.3 (95% CI 1.3,1.3)]。手术后,253 例患者 (18.7%) 在监测期间发生复发性黑色素瘤,尽管基线NLR与复发风险之间无统计学显著相关性 [校正HR 0.9 (0.7,1.1)]。 结论: NLR与就诊时黑色素瘤的体积相关,并可能预测隐匿性前哨淋巴结转移。需要进一步的前瞻性工作来研究NLR如何与其他临床病理变量进行建模,以预测结果,并了解黑色素瘤手术后NLR的时间变化。

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影响因子:2.93
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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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