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Women with fair phenotypes seem to confer a survival advantage in a low UV milieu. A nested matched case control study.

具有公平表型的女性似乎在低UV环境中赋予生存优势。嵌套匹配的病例对照研究。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0228582
  • 作者列表:"Lindqvist PG","Epstein E","Landin-Olsson M","Åkerlund M","Olsson H
  • 发表时间:2020-01-30
Abstract

BACKGROUND:Sun exposure in combination with skin pigmentation is the main determinant for vitamin D status. Human skin color seems to be adapted and optimized for regional sun ultraviolet (UV) intensity. However, we do not know if fair, UV-sensitive skin is a survival advantage in regions with low UV radiation. METHODS:A population-based nested case-control study of 29,518 Caucasian women, ages 25 to 64 years from Southern Sweden who responded to a questionnaire regarding risk-factors for malignant melanoma in 1990 and followed for 25 years. For each fair woman, defined as having red hair or freckles (n = 11,993), a control was randomly selected from all non-fair women from within the cohort of similar age, smoking habits, education, marital status, income, and comorbidity, i.e., 11,993 pairs. The main outcome was the difference in all-cause mortality between fair and non-fair women in a low UV milieu, defined as living in Sweden and having low-to-moderate sun exposure habits. Secondary outcomes were mortality by sun exposure, and among those non-overweight. RESULTS:In a low UV milieu, fair women were at a significantly lower all-cause mortality risk as compared to non-fair women (log rank test p = 0.04) with an 8% lower all-cause mortality rate (hazard ratio [HR] = 0.92, 95% CI 0.84‒1.0), including a 59% greater risk of dying from skin cancer among fair women (HR 1.59, 95% CI 1.26‒2.0). Thus, it seem that the beneficial health effect from low skin coloration outweigh the risk of skin cancer at high latitudes. CONCLUSION:In a region with low UV milieu, evolution seems to improve all-cause survival by selecting a fair skin phenotype, i.e., comprising fair women with a survival advantage.

摘要

背景: 日晒结合皮肤色素沉着是维生素d状态的主要决定因素。人类的肤色似乎是适应和优化的区域太阳紫外线 (UV) 强度。然而,我们不知道是否公平,紫外线敏感的皮肤是低紫外线辐射地区的生存优势。 方法: 一项基于 29,518 名高加索妇女的人群巢式病例对照研究,年龄 25 ~ 64 岁,来自瑞典南部,1990 年回答了一份关于恶性黑色素瘤危险因素的问卷,并随访了 25 年。对于每个漂亮的女性,定义为有红色头发或雀斑 (n = 11,993),从年龄相似、吸烟习惯、教育、婚姻状况、收入和共病,即,11,993 双。主要结果是低紫外线环境中公平和非公平女性的全因死亡率差异,定义为生活在瑞典,有低至中度的阳光暴露习惯。次要结局是阳光照射的死亡率,以及那些非超重的死亡率。 结果: 在低紫外线环境下,公平女性的全因死亡风险显著低于非公平女性 (log rank检验p = 0.04) 全因死亡率降低 8% (风险比 [HR] = 0.92,95% CI 0.84-1.0),包括公平女性死于皮肤癌的风险增加 59% (HR 1.59,95% CI 1.26-2.0)。因此,它似乎是有益的健康效果从低皮肤着色超过风险的皮肤癌在高纬度地区。 结论: 在低UV环境的地区,进化似乎通过选择公平的皮肤表型来提高全因生存率,即包括具有生存优势的公平女性。

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影响因子:0.96
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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