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New Systematic Therapies and Trends in Cutaneous Melanoma Deaths Among US Whites, 1986-2016.

美国白人皮肤黑色素瘤死亡的新系统疗法和趋势,1986-2016。

  • 影响因子:3.12
  • DOI:10.2105/AJPH.2020.305567
  • 作者列表:"Berk-Krauss J","Stein JA","Weber J","Polsky D","Geller AC
  • 发表时间:2020-05-01
Abstract

:Objectives. To determine the effect of new therapies and trends toward reduced mortality rates of melanoma.Methods. We reviewed melanoma incidence and mortality among Whites (the group most affected by melanoma) in 9 US Surveillance, Epidemiology, and End Results registry areas that recorded data between 1986 and 2016.Results. From 1986 to 2013, overall mortality rates increased by 7.5%. Beginning in 2011, the US Food and Drug Administration approved 10 new treatments for metastatic melanoma. From 2013 to 2016, overall mortality decreased by 17.9% (annual percent change [APC] = -6.2%; 95% confidence interval [CI] = -8.7%, -3.7%) with sharp declines among men aged 50 years or older (APC = -8.3%; 95% CI = -12.2%, -4.1%) starting in 2014. This recent, multiyear decline is the largest and most sustained improvement in melanoma mortality ever observed and is unprecedented in cancer medicine.Conclusions. The introduction of new therapies for metastatic melanoma was associated with a significant reduction in population-level mortality. Future research should focus on developing even more effective treatments, identifying biomarkers to select patients most likely to benefit, and renewing emphasis on public health approaches to reduce the number of patients with advanced disease.

摘要

: 目标。确定新疗法的效果和降低黑色素瘤死亡率的趋势。方法.我们在 9 个美国监测流行病学学和最终结果登记领域回顾了白人 (黑色素瘤影响最大的群体) 的黑色素瘤发病率和死亡率,记录了 1986 年至 2016 年之间的数据。结果。从 1986 到 2013 年,总体死亡率增加了 7.5%。从 2011 年开始,美国食品和药物管理局批准了 10 种治疗转移性黑色素瘤的新方法。从 2013 到 2016 年,总体死亡率下降了 17.9% (年百分比变化 [APC] =-6.2%; 95% 置信区间 [CI] =-8.7%,-3.7%) 从 2014 年开始,50 岁或以上的男性急剧下降 (apc =-8.3%; 95% ci =-12.2%,-4.1%)。这一最近的,多年的下降是有史以来观察到的黑色素瘤死亡率的最大和最持续的改善,在癌症医学中是前所未有的。结论.转移性黑色素瘤新疗法的引入与人群水平死亡率的显著降低相关。未来的研究应侧重于开发更有效的治疗方法,确定生物标志物以选择最有可能受益的患者,并重新强调公共卫生方法以减少晚期疾病患者的数量。

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影响因子:2.93
发表时间:2020-01-01
DOI:10.1016/j.jaad.2019.04.067
作者列表:["Pham CT","Juhasz M","Sung CT","Mesinkovska NA"]

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影响因子:0.96
发表时间:2020-01-01
DOI:10.1097/DAD.0000000000001459
作者列表:["Lang UE","Love NR","Cheung C","McCalmont TH","Kim J"]

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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