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Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects.

Smoothed受体抑制剂vismodegib治疗基底细胞癌: 疗效和副作用的回顾性分析。

  • 影响因子:1.76
  • DOI:10.1080/09546634.2019.1601155
  • 作者列表:"Bánvölgyi A","Anker P","Lőrincz K","Kiss N","Márton D","Fésűs L","Gyöngyösi N","Wikonkál N
  • 发表时间:2020-06-01
Abstract

:Background: Smoothened receptor inhibitor vismodegib is indicated to treat locally advanced basal cell carcinoma (laBCC) and lesions in nevoid basal cell carcinoma syndrome (NBCCS).Methods: We treated 11 patients - including four NBCCS and seven laBCC patients - with vismodegib at our department.Results: Complete remission was achieved in three cases, without relapse after discontinuation. Two of the aforementioned patients had NBCCS, in their cases further treatment might be needed. Two patients showed improvement, but later passed away due to unrelated conditions. Two patients with laBCC initially showed remission, then the treatment was suspended due to side effects. After re-administration of the drug, loss of efficacy was observed. We did not observe therapy resistance in our NBCCS group. The rest of the patients showed good response to therapy, but have not reached full remission yet. The main side effects of vismodegib were muscle cramps, dysgeusia, nausea and alopecia. The frequency of adverse events did not show significant differences between the patient groups.Conclusions: Our results show that vismodegib therapy is effective in the treatment of BCC; however, side effects are often severe. Since the suspension of treatment can lead to therapy resistance, the management of side effects is of great importance.

摘要

: 背景: Smoothened受体抑制剂vismodegib用于治疗局部晚期基底细胞癌 (laBCC) 和痣样基底细胞癌综合征 (NBCCS) 的病变。方法: 我们在我科用vismodegib治疗了 11 例患者,包括 4 例NBCCS和 7 例laBCC患者。结果: 3 例获得完全缓解,停药后无复发。上述患者中有 2 例患有NBCCS,在他们的病例中可能需要进一步治疗。两名患者显示改善,但后来因无关疾病而去世。2 例laBCC患者最初表现为缓解,随后因副作用暂停治疗。再次给药后,观察到疗效丧失。我们在NBCCS组中未观察到治疗耐药。其余患者对治疗反应良好,但尚未达到完全缓解。Vismodegib的主要副作用是肌肉痉挛、味觉障碍、恶心和脱发。不良事件的频率在患者组之间没有显示出显著差异。结论: 我们的结果表明vismodegib治疗BCC有效; 然而,副作用往往是严重的。由于暂停治疗可导致治疗抵抗,因此副作用的处理非常重要。

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影响因子:0.96
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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