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Plasmacytoid dendritic cells in keratoacanthoma and squamous cell carcinoma: A blinded study of CD123 as a diagnostic marker.

浆细胞样树突状细胞在角化棘皮瘤和鳞状细胞癌中的作用: CD123 作为诊断标志物的盲法研究。

  • 影响因子:1.26
  • DOI:10.1111/cup.13573
  • 作者列表:"Fraga GR","Chow P
  • 发表时间:2020-01-01
Abstract

BACKGROUND:Histopathologic distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is challenging. We surmised that a discriminatory immunostain would be clinically meaningful. Previous investigators have found CD123-positive plasmacytoid dendritic cells (PDCs) are more prominent in KA than SCC. We sought to determine if CD123 immunostaining might have value as a diagnostic test for distinguishing KA from SCC. METHODS:We used blinded, semi-automated image analysis to compare CD123 expression in 66 KAs and 63 SCCs in a tissue microarray. RESULTS:PDCs were present in both KA and SCC. Mean PDC frequency was higher in KA than SCC (14.2 vs 11.2 mean cells/0.0945 square mm) but the difference was not statistically significant (P = 0.1240). There was no significant difference in mean PDC cluster frequency, mean intratumoral PDC frequency, or the percentage of PDCs as proportion of the total mononuclear inflammatory cell infiltrate between KA and SCC. CONCLUSION:CD123 immunostaining is not a clinically useful test for distinguishing KA from SCC.

摘要

背景: 角化棘皮瘤 (KA) 和鳞状细胞癌 (SCC) 的组织病理学鉴别具有挑战性。我们推测,歧视性免疫染色将具有临床意义。以前的研究人员发现CD123-positive浆细胞样树突状细胞 (PDCs) 在KA中比SCC更突出。我们试图确定CD123 免疫染色是否有价值作为区分KA和SCC的诊断test。 方法: 我们采用盲法、半自动图像分析比较组织芯片中 66 个KAs和 63 个scc中CD123 的表达。 结果: PDCs在KA和SCC中均存在。KA的平均PDC频率高于SCC (14.2 vs 11.2 平均细胞/0.0945 平方mm),但差异无统计学意义 (P = 0.1240)。KA和SCC之间的平均PDC簇频率、平均瘤内PDC频率或PDCs占总单核炎性细胞浸润的比例无显著差异。 结论: CD123 免疫染色不是鉴别KA和SCC的临床test。

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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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