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Chemotherapy Following PD-1 Inhibitor Blockade in Patients with Unresectable Stage III/Stage IV Metastatic Melanoma: A Single Academic Institution Experience.

不可切除的III期/IV期转移性黑色素瘤患者PD-1 抑制剂阻断后的化疗: 单个学术机构的经验。

  • 影响因子:2.22
  • DOI:10.1159/000504578
  • 作者列表:"Karachaliou GS","Ayvali F","Collichio FA","Lee CB","Ivanova A","Ollila DW","Moschos SJ
  • 发表时间:2020-01-01
Abstract

:Retrospective case studies in various cancers have shown clinical benefit from chemotherapy following PD-1 inhibitor progression. We asked whether we see a similar clinical benefit with chemotherapy following PD-1 inhibitor progression in metastatic melanoma. We performed a retrospective study in patients with metastatic melanoma, who had received PD-1 inhibitor-based treatments, subsequently progressed, and eventually received chemotherapy. We identified 25 patients (median age 58 years; range 31-77 years; 13 females). Most patients had cutaneous melanoma (72%), were BRAFV600E-negative (75%), and received single-agent temozolomide (84%). At a median follow-up of 21.0 months (range: 4.1-154.2 months), 2 patients had durable response to chemotherapy (progression-free survival is 31.9+ and 21.6+ months, respectively), and 1 patient had a partial, short-term response. We conclude that in this poor prognosis group administration of chemotherapy has a 12% response rate that can be durable. Overall, the clinical benefit is not inferior to that of PD-1 inhibitor-based treatments.

摘要

: 各种癌症的回顾性病例研究表明,PD-1 抑制剂进展后化疗可获得临床益处。我们询问,在转移性黑色素瘤中,PD-1 抑制剂进展后,化疗是否有类似的临床获益。我们对转移性黑色素瘤患者进行了一项回顾性研究,这些患者接受了基于PD-1 抑制剂的治疗,随后进展,最终接受了化疗。我们确定了 25 例患者 (中位年龄 58 岁; 范围 31-77 岁; 13 例女性)。大多数患者有皮肤黑色素瘤 (72%),BRAFV600E-negative (75%),并接受单药替莫唑胺 (84%)。中位随访 21.0 个月 (范围: 4.1-154.2 个月),2 例患者对化疗有持久反应 (无进展生存期为 31.9 + 和 21.6 + 个月,分别) 和 1 例患者有部分短期反应。我们的结论是,在这个预后不良的组中,化疗的给药有 12% 的反应率,可以持久。总体而言,临床效益不逊于PD-1 抑制剂为基础的治疗。

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影响因子:0.96
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皮肤肿瘤方向

皮肤肿瘤是发生在皮肤的细胞增生性疾病,是一种常见病。发生于皮内或皮下组织的新生物,种类很多,临床上分良性肿瘤和恶性肿瘤。恶性肿瘤可以不断增殖,引起转移,威胁生命,称为皮肤癌。

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