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Mesenchymal stem cells as a potential therapy for COVID-19.

间充质干细胞作为新型冠状病毒肺炎的潜在疗法。

  • 影响因子:4.83
  • DOI:10.1186/s13287-020-01678-8
  • 作者列表:"Liu S","Peng D","Qiu H","Yang K","Fu Z","Zou L
  • 发表时间:2020-05-04
Abstract

:The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. The main pathologic features of severe or critical COVID-19 were consistent with acute lung injure (ALI)/acute respiratory distress syndrome (ARDS), characterized by cellular fibromyxoid exudates, extensive pulmonary inflammation, pulmonary edema, and hyaline membrane formation. Mesenchymal stem cells (MSCs) can balance the inflammatory response and has been mentioned to be effective on ALI/ARDS from both infectious and noninfectious causes previously, presenting an important opportunity to be applied to COVID-19. In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19.

摘要

2019 年全球新型冠状病毒疾病 (新型冠状病毒肺炎) 的爆发正在迅速成为一个主要问题。重症病例的数量在全球范围内急剧增加,而具体的治疗选择却很少。重症或危重新型冠状病毒肺炎的主要病理特征为急性肺损伤 (ALI)/急性呼吸窘迫综合征 (ARDS),表现为细胞纤维黏液样渗出,广泛肺部炎症,肺水肿,和透明膜的形成。间充质干细胞 (Mesenchymal stem cells,MSCs) 可以平衡炎症反应,以前被认为对感染性和非感染性原因的ALI/ARDS有效,为应用于新型冠状病毒肺炎提供了重要机会。在这篇评论中,我们总结了MSCs治疗ALI/ARDS的临床试验,并提出MSCs有望成为严重或危重新型冠状病毒肺炎的替代疗法。

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DOI:10.3346/jkms.2020.35.e79
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影响因子:4.36
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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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