Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran.
伊朗南部 2019 新型冠状病毒疾病 (新型冠状病毒肺炎) 的流行病学和临床特征。
- 作者列表："Shahriarirad R","Khodamoradi Z","Erfani A","Hosseinpour H","Ranjbar K","Emami Y","Mirahmadizadeh A","Lotfi M","Shirazi Yeganeh B","Dorrani Nejad A","Hemmati A","Ebrahimi M","Moghadami M
BACKGROUND:In March 2020, the WHO declared the novel coronavirus (COVID-19) outbreak a global pandemic. Although the number of infected cases is increasing, information about its clinical characteristics in the Middle East, especially in Iran, a country which is considered to be one of the most important focal points of the disease in the world, is lacking. To date, there is no available literature on the clinical data on COVID-19 patients in Iran. METHODS:In this multicenter retrospective study, 113 hospitalized confirmed cases of COVID-19 admitted to university affiliated hospitals in Shiraz, Iran from February 20 to March 20 were entered in the study. RESULTS:The mean age was 53.75 years and 71 (62.8%) were males. The most common symptoms at onset were fatigue (75: 66.4%), cough (73: 64.6%), and fever (67: 59.3%). Laboratory data revealed significant correlation between lymphocyte count (P value = 0.003), partial thromboplastin time (P value = 0.000), international normalized ratio (P value = 0.000) with the severity of the disease. The most common abnormality in chest CT scans was ground-glass opacity (77: 93.9%), followed by consolidation (48: 58.5%). Our results revealed an overall 8% (9 out of 113 cases) mortality rate among patients, in which the majority was among patients admitted to the ICU (5: 55.6%). CONCLUSION:Evaluating the clinical data of COVID-19 patients and finding the source of infection and studying the behavior of the disease is crucial for understanding the pandemic.
背景: 2020 年 3 月，世卫组织宣布新型冠状病毒 (新型冠状病毒肺炎) 爆发为全球大流行。虽然感染病例的数量正在增加，但有关其在中东，特别是伊朗的临床特征的信息，缺乏一个被认为是世界上疾病最重要焦点之一的国家。迄今为止，还没有关于伊朗新型冠状病毒肺炎患者的临床数据的文献。 方法: 在这项多中心回顾性研究中，纳入了 2 月 20 日至 3 月 20 日期间在伊朗设拉子大学附属医院住院的 113 确诊病例的新型冠状病毒肺炎。 结果: 平均年龄为 53.75 岁，71 例 (62.8%) 为男性。最常见的症状发病乏力 (75 ∶ 66.4%) 、咳嗽 (73: 64.6%)，发热 (67: 59.3%).实验室数据显示淋巴细胞计数 (p值 = 0.003) 、部分凝血活酶时间 (p值 = 0.000) 、国际标准化比值 (p值 = 0.000) 之间存在显著相关性随着疾病的严重程度。胸部ct扫描最常见的异常是磨玻璃影 (77: 93.9%)，其次是实变 (48: 58.5%)。我们的结果显示患者中总体死亡率 8% (113 例中的 9 例)，其中大多数是入住ICU的患者 (5: 55.6%)。 结论: 评估新型冠状病毒肺炎患者的临床资料，发现传染源，研究疾病的行为，对了解大流行至关重要。
METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.