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Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement.

纳米颗粒在流感亚单位疫苗开发中的应用: 免疫原性增强。

  • 影响因子:3.20
  • DOI:10.1111/irv.12697
  • 作者列表:"Khalaj-Hedayati A","Chua CLL","Smooker P","Lee KW
  • 发表时间:2020-01-01
Abstract

:The threat of novel influenza infections has sparked research efforts to develop subunit vaccines that can induce a more broadly protective immunity by targeting selected regions of the virus. In general, subunit vaccines are safer but may be less immunogenic than whole cell inactivated or live attenuated vaccines. Hence, novel adjuvants that boost immunogenicity are increasingly needed as we move toward the era of modern vaccines. In addition, targeting, delivery, and display of the selected antigens on the surface of professional antigen-presenting cells are also important in vaccine design and development. The use of nanosized particles can be one of the strategies to enhance immunogenicity as they can be efficiently recognized by antigen-presenting cells. They can act as both immunopotentiators and delivery system for the selected antigens. This review will discuss on the applications, advantages, limitations, and types of nanoparticles (NPs) used in the preparation of influenza subunit vaccine candidates to enhance humoral and cellular immune responses.

摘要

: 新型流感感染的威胁引发了研究努力,开发亚单位疫苗,通过针对病毒的选定区域诱导更广泛的保护性免疫。一般来说,亚单位疫苗比全细胞灭活或减毒活疫苗更安全,但免疫原性可能较低。因此,随着我们走向现代疫苗时代,越来越需要提高免疫原性的新型佐剂。此外,靶向、递送和展示专业抗原呈递细胞表面的选定抗原在疫苗设计和开发中也很重要。纳米颗粒的使用可以是增强免疫原性的策略之一,因为它们可以被抗原呈递细胞有效识别。它们既可以作为免疫增强剂,也可以作为所选抗原的递送系统。本综述将讨论用于制备流感亚单位疫苗候选物以增强体液和细胞免疫应答的纳米颗粒 (NPs) 的应用、优点、局限性和类型。

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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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