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Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.

肺隐球菌病: 免疫功能正常和免疫功能低下患者隐球菌抗原检测和x线摄影的比较。

  • 影响因子:2.79
  • DOI:10.1186/s12879-020-4818-1
  • 作者列表:"Min J","Huang K","Shi C","Li L","Li F","Zhu T","Deng H
  • 发表时间:2020-01-30
Abstract

BACKGROUND:We compared the cryptococcal antigen detection and imaging findings between immunocompetent and immunocompromised patients in whom pulmonary cryptococcosis had been diagnosed. The aim of our study was to determine whether the patient's immune status and radiography affect the detection of cryptococcal antigen. METHODS:According to whether they took immunosuppressive drugs or not, seventy and eight adult patients with pulmonary cryptococcosis were divided into two groups: the immunocompetent group and the immunocompromised group. According to the detection of CrAg, each group was divided into the CrAg+ group and the CrAg- group. Then, clinical records, laboratory examinations and computed tomography findings were collected and analyzed. RESULTS:No difference was found in baseline characteristics, clinical symptoms, and laboratory investigations. By comparing CrAg detection in these two groups, it was found that the number of CrAg+ cases in the immunocompetent group was more than that in the immunocompromised group. And in the immunocompetent group, diffuse lesions were more common in CrAg+ group and limited lesions were more frequently observed in CrAg- group. CONCLUSIONS:The patient's immune status and radiography would affect the detection of cryptococcal antigen. And serum CrAg could be a useful tool for the diagnosis of pulmonary cryptococcosis in immunocompetent patients with extensive lung involvement.

摘要

背景: 我们比较了免疫功能正常和免疫功能低下的肺隐球菌病患者的隐球菌抗原检测和影像学表现。我们研究的目的是确定患者的免疫状态和摄片是否影响隐球菌抗原的检测。 方法: 根据是否服用免疫抑制剂,将 78 例成人肺隐球菌病患者分为免疫功能正常组和免疫功能低下组。根据CrAg的检测,将各组分为CrAg + 组和CrAg-组。然后,收集临床记录、实验室检查和计算机断层扫描结果并进行分析。 结果: 在基线特征、临床症状和实验室检查方面未发现差异。通过比较这两组的CrAg检测,发现免疫活性组的CrAg + 病例数多于免疫缺陷组。免疫功能正常组弥漫性病变以CrAg + 组多见,局限性病变以CrAg-组多见。 结论: 患者的免疫状态和摄片会影响隐球菌抗原的检测。血清CrAg可作为肺部广泛受累的免疫功能正常患者肺隐球菌病诊断的有用工具。

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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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