A 55-Day-Old Female Infant Infected With 2019 Novel Coronavirus Disease: Presenting With Pneumonia, Liver Injury, and Heart Damage.
一名 55 日龄女婴感染 2019 新型冠状病毒疾病: 表现为肺炎、肝损伤和心脏损害。
- 作者列表："Cui Y","Tian M","Huang D","Wang X","Huang Y","Fan L","Wang L","Chen Y","Liu W","Zhang K","Wu Y","Yang Z","Tao J","Feng J","Liu K","Ye X","Wang R","Zhang X","Zha Y
BACKGROUND:Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were mainly based on information from adult populations. Limited data are available for children with COVID-19, especially for infected infants. METHODS:We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. RESULTS:This case highlights that children with COVID-19 can also present with multiple organ damage and rapid disease changes. CONCLUSIONS:When managing such infant patients with COVID-19, frequent and careful clinical monitoring is essential.
背景: 以往关于 2019 新型冠状病毒 (新型冠状病毒肺炎) 引起的肺炎暴发的研究主要基于来自成年人群的信息。新型冠状病毒肺炎儿童的数据有限，尤其是受感染的婴儿。 方法: 我们报道了一例在中国确诊的 55 天大的新型冠状病毒肺炎病例，描述了患者的鉴别、诊断、临床过程和治疗。包括疾病从第 7 天到第 11 天的疾病进展。 结果: 本病例提示新型冠状病毒肺炎患儿也可出现多器官损害，病情变化快。 结论: 在处理这些新型冠状病毒肺炎的婴儿患者时，经常和仔细的临床监测是必不可少的。
METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.