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Collateral damage: necroptosis in the development of lung injury.

副损伤: 肺损伤发展过程中的坏死性坏死。

  • 影响因子:3.82
  • DOI:10.1152/ajplung.00065.2019
  • 作者列表:"Faust H","Mangalmurti NS
  • 发表时间:2020-02-01
Abstract

:Cell death is increasingly recognized as a driving factor in the development of acute lung injury. Necroptosis, an immunogenic regulated cell death program important in innate immunity, has been implicated in the development of lung injury in a diverse range of conditions. Characterized by lytic cell death and consequent extracellular release of endogenous inflammatory mediators, necroptosis can be both beneficial and deleterious to the host, depending on the context. Here, we review recent investigations linking necroptosis and the development of experimental lung injury. We assess the consequences of necroptosis during bacterial pneumonia, viral infection, sepsis, and sterile injury, highlighting increasing evidence from in vitro studies, animal models, and clinical studies that implicates necroptosis in the pathogenesis of ARDS. Lastly, we highlight current challenges in translating laboratory findings to the bedside.

摘要

: 细胞死亡越来越被认为是急性肺损伤发展的驱动因素。坏死性凋亡是一种免疫原性调节的细胞死亡程序,在天然免疫中很重要,在多种条件下与肺损伤的发生有关。以溶解细胞死亡和随之而来的内源性炎症介质的细胞外释放为特征,坏死性凋亡对宿主既有益又有害,这取决于上下文。在这里,我们回顾了最近的研究联系坏死性囊肿和实验性肺损伤的发展。我们评估了细菌性肺炎、病毒感染、败血症和无菌损伤期间坏死性凋亡的后果,强调了来自体外研究、动物模型的越来越多的证据,和临床研究,提示坏死性凋亡在ARDS的发病机制。最后,我们强调了目前将实验室发现转化到床边的挑战。

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翻译标题与摘要 下载文献
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发表时间:2020-04-01
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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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