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Is COVID-19 receiving ADE from other coronaviruses?

新型冠状病毒肺炎收到其他冠状病毒的ADE?

  • 影响因子:2.45
  • DOI:10.1016/j.micinf.2020.02.006
  • 作者列表:"Tetro JA
  • 发表时间:2020-03-01
Abstract

:One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.

摘要

: 关于目前冠状病毒流行新型冠状病毒肺炎最令人困惑的问题之一是在中国湖北省观察到的病例的严重程度与世界其他地方发生的病例之间的差异。一个可能的答案是由于先前暴露于其他冠状病毒而导致的SARS-CoV-2 的抗体依赖性增强 (ADE)。ADE调节免疫反应,可引起持续的炎症、淋巴细胞减少和/或细胞因子风暴,其中一项或全部在严重病例和死亡病例中均有记录。ADE还要求事先暴露于类似的抗原表位,推测可能在当地病毒中循环,使其成为观察到的严重病例和死亡的地理限制的可能解释。

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DOI:10.3346/jkms.2020.35.e79
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翻译标题与摘要 下载文献
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发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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