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Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study.

冠状病毒病 2019 合并肝损伤的非ICU住院患者的临床特征: 一项回顾性研究。

  • 影响因子:3.87
  • DOI:10.1111/liv.14449
  • 作者列表:"Xie H","Zhao J","Lian N","Lin S","Xie Q","Zhuo H
  • 发表时间:2020-06-01
Abstract

BACKGROUND & AIMS:Coronavirus disease 2019 (COVID-19) has raised world concern for global epidemic since December, 2019. Limited data are available for liver function in COVID-19 patients. We aimed to investigate the risk factors related to liver injury in the COVID-19 patients. METHODS:A retrospective study was performed in non-ICU Ward at Jinyintan Hospital from February 2, 2020 to February 23, 2020. Consecutively confirmed COVID-19 discharged cases were enrolled. The clinical characteristics of patients with liver injury and without liver injury were compared. RESULTS:A total of 79 COVID-19 patients were included. 31.6%, 35.4% and 5.1% COVID-19 patients had elevated levels of alanine transaminase (ALT), aspartate aminotransferase (AST) and bilirubin respectively. Median value of ALT, AST and bilirubin for entire cohort was 36.5 (17.5 ~ 71.5) U/L, 34.5 (25.3 ~ 55.3) U/L and 12.7 (8.1 ~ 15.4) mmol/L respectively. There were no significant differences in age, previous medical history and symptoms between the two groups. Males were more likely to have liver injury when infected with COVID-19 (P < .05); compared with patients without liver injury, patients with liver injury had increased levels of white blood cell counts, neutrophils, CRP and CT score (P < .05) and had a longer length of stay (P < .05). Logistic regression analyses suggested that the extent of pulmonary lesions on CT was a predictor of liver function damage (P < .05). CONCLUSIONS:Liver injury is common in non-ICU hospitalized COVID-19 patients. It may be related to systemic inflammation. Intense monitoring and evaluation of liver function in patients with severe pulmonary imaging lesions should be considered.

摘要

背景与目的: 自 2019 年 12 月以来,冠状病毒疾病 2019 (新型冠状病毒肺炎) 已经引起了全世界对全球流行的关注。新型冠状病毒肺炎患者的肝功能数据有限。本研究旨在探讨新型冠状病毒肺炎患者肝损伤的相关危险因素。 方法: 回顾性研究 2 0 0 年 2 月 ~ 2 0 0 年 2 月在金银滩医院非ICU病房进行。连续确诊新型冠状病毒肺炎例出院病例入组。比较有肝损伤与无肝损伤患者的临床特点。 结果: 共纳入 79 例新型冠状病毒肺炎患者。新型冠状病毒肺炎患者丙氨酸转氨酶 (ALT) 、天冬氨酸转氨酶 (AST) 和胆红素水平升高分别为 31.6% 、 35.4% 和 5.1%。整个队列ALT、AST和bilir u bin的中位val u e为 36.5 (17.5 ~ 71.5) U/L,34.5 (25.3 ~ 55.3) U/L和 12.7 (8.1 ~ 15.4) mmol/L分别。两组患者在年龄、既往病史、症状等方面差异无统计学意义。男性在感染新型冠状病毒肺炎时更易发生肝损伤 (P < .05); 与无肝损伤患者相比,肝损伤患者白细胞计数、中性粒细胞、CRP和CT评分 (P <.05),住院时间较长 (P <.05)。Logistic回归分析提示CT肺部病变程度是肝功能损害的预测因子 (P <.05)。 结论: 肝损伤常见于非ICU住院新型冠状病毒肺炎患者。可能与全身炎症有关。应考虑对肺部严重影像学病变患者进行强烈的肝功能监测和评估。

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影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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